Science Letters： Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension

Idiopathic pulmonary arterial hypertension （IPAH） is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2007, Vol.8 (4), p.221-227
Main Author: YU Min WANG Xing-xiang ZHANG Fu-rong SHANG Yun-peng DU Yu-xi CHEN Hong-juan CHEN Jun-zhu
Format: Article
Language:English
Subjects:
二维凝胶电泳
先天性肺动脉高压
蛋白质组分析
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Summary:Idiopathic pulmonary arterial hypertension （IPAH） is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques, profiling of human plasma proteome becomes more feasible in searching for disease-related markers. In present study, we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum. Thirteen spots had changed significantly in IPAH compared with healthy controls and were identified by LC-MS/MS. Alpha- 1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.
ISSN:1673-1581
1862-1783