NF‐YCs modulate histone variant H2A.Z deposition to regulate photomorphogenic growth in Arabidopsis

In plants, light signals trigger a photomorphogenic program involving transcriptome changes, epigenetic regulation, and inhibited hypocotyl elongation. The evolutionarily conserved histone variant H2A.Z, which functions in transcriptional regulation, is deposited in chromatin by the SWI2/SNF2‐RELATE...

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Published in:Journal of integrative plant biology 2021-06, Vol.63 (6), p.1120-1132
Main Authors: Zhang, Chunyu, Qian, Qian, Huang, Xiang, Zhang, Wenbin, Liu, Xu, Hou, Xingliang
Format: Article
Language:English
Subjects:
Actin
Arabidopsis
ARP6
Chromatin
Deposition
Elongation
Epigenetics
Gene expression
Gene regulation
H2A.Z deposition
Histones
hypocotyl elongation
Irradiation
light
Light irradiation
NF‐YC
Photomorphogenesis
Plant growth
Radiation
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Summary:In plants, light signals trigger a photomorphogenic program involving transcriptome changes, epigenetic regulation, and inhibited hypocotyl elongation. The evolutionarily conserved histone variant H2A.Z, which functions in transcriptional regulation, is deposited in chromatin by the SWI2/SNF2‐RELATED 1 complex (SWR1c). However, the role of H2A.Z in photomorphogenesis and its deposition mechanism remain unclear. Here, we show that in Arabidopsis thaliana, H2A.Z deposition at its target loci is induced by light irradiation via NUCLEAR FACTOR‐Y, subunit C (NF‐YC) proteins, thereby inhibiting photomorphogenic growth. NF‐YCs physically interact with ACTIN‐RELATED PROTEIN6 (ARP6), a key component of the SWR1c that is essential for depositing H2A.Z, in a light‐dependent manner. NF‐YCs and ARP6 function together as negative regulators of hypocotyl growth by depositing H2A.Z at their target genes during photomorphogenesis. Our findings reveal an important role for the histone variant H2A.Z in photomorphogenic growth and provide insights into a novel transcription regulatory node that mediates H2A.Z deposition to control plant growth in response to changing light conditions. Light induces deposition of the histone variant H2A.Z at hypocotyl elongation‐related genes to promote photomorphogenic growth, and during photomorphogenesis this process is regulated by NUCLEAR FACTOR‐YC‐ACTIN‐RELATED PROTEIN6 module, a novel transcription regulatory node.
ISSN:1672-9072
1744-7909
DOI:10.1111/jipb.13109