Ultrasmall Au10−12(SG)10−12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy

Radiosensitizers can increase local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, a new class of radiosensitizers is reported, which contain several gold (Au) atoms embedded inside a peptide shell (e.g., A...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2014-07, Vol.26 (26), p.4565-4568
Main Authors: Zhang, Xiao-Dong, Luo, Zhentao, Chen, Jie, Shen, Xiu, Song, Shasha, Sun, Yuanming, Fan, Saijun, Fan, Feiyue, Leong, David Tai, Xie, Jianping
Format: Article
Language:English
Subjects:
gold nanoclusters
gold nanomolecules
radiosensitization
radiotherapy
tumor uptake
Online Access:Get full text
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Summary:Radiosensitizers can increase local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, a new class of radiosensitizers is reported, which contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10–12 (SG)10–12) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201400866