Ultrasmall Au10−12(SG)10−12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy

Radiosensitizers can increase local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, a new class of radiosensitizers is reported, which contain several gold (Au) atoms embedded inside a peptide shell (e.g., A...

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Published in:Advanced materials (Weinheim) 2014-07, Vol.26 (26), p.4565-4568
Main Authors: Zhang, Xiao-Dong, Luo, Zhentao, Chen, Jie, Shen, Xiu, Song, Shasha, Sun, Yuanming, Fan, Saijun, Fan, Feiyue, Leong, David Tai, Xie, Jianping
Format: Article
Language:English
Subjects:
gold nanoclusters
gold nanomolecules
radiosensitization
radiotherapy
tumor uptake
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container_end_page 4568
container_issue 26
container_start_page 4565
container_title Advanced materials (Weinheim)
container_volume 26
creator Zhang, Xiao-Dong
Luo, Zhentao
Chen, Jie
Shen, Xiu
Song, Shasha
Sun, Yuanming
Fan, Saijun
Fan, Feiyue
Leong, David Tai
Xie, Jianping
description Radiosensitizers can increase local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, a new class of radiosensitizers is reported, which contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10–12 (SG)10–12) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.
doi_str_mv 10.1002/adma.201400866
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subjects gold nanoclusters
gold nanomolecules
radiosensitization
radiotherapy
tumor uptake
title Ultrasmall Au10−12(SG)10−12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy
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