Farnesyltransferase Inhibitors Inhibit the Growth of Malaria Parasites In Vitro and In Vivo

The inhibition of farnesyltransferase was recently suggested as a new strategy for malaria therapy. A class of farnesyltransferase inhibitors such as 1 has been prepared which have in vivo activity in a murine malaria model. These inhibitors significantly reduce the farnesylation of parasite protein...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2003-12, Vol.43 (2), p.251-254
Main Authors: Wiesner, Jochen, Kettler, Katja, Sakowski, Jacek, Ortmann, Regina, Katzin, Alejandro M., Kimura, Emília A., Silber, Katrin, Klebe, Gerhard, Jomaa, Hassan, Schlitzer, Martin
Format: Article
Language:English
Subjects:
drug design
enzyme inhibitors
farnesyltransferase
malaria
medicinal chemistry
Online Access:Get full text
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Summary:The inhibition of farnesyltransferase was recently suggested as a new strategy for malaria therapy. A class of farnesyltransferase inhibitors such as 1 has been prepared which have in vivo activity in a murine malaria model. These inhibitors significantly reduce the farnesylation of parasite proteins.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200351169