Cover Picture: Fluorous Synthesis of 18F Radiotracers with the [18F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process (Angew. Chem. Int. Ed. 3/2009)

Time is of the essence in preparing 18F‐labeled radiotracers when the half‐life of 18F is 109.7 minutes. In their Communication on page 586, V. Gouverneur and co‐workers report the radiosynthesis of various prosthetic groups and 18F radiotracers from fluorous‐tagged precursors. This approach allows...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2009-01, Vol.48 (3), p.413-413
Main Authors: Bejot, Romain, Fowler, Thomas, Carroll, Laurence, Boldon, Sophie, Moore, Jane E., Declerck, Jérôme, Gouverneur, Véronique
Format: Article
Language:English
Subjects:
fluorine
positron emission tomography
radiopharmaceuticals
synthetic methods
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Summary:Time is of the essence in preparing 18F‐labeled radiotracers when the half‐life of 18F is 109.7 minutes. In their Communication on page 586, V. Gouverneur and co‐workers report the radiosynthesis of various prosthetic groups and 18F radiotracers from fluorous‐tagged precursors. This approach allows for fast and convenient purification of 18F‐radiolabeled material (FSPE=fluorous solid phase extraction). Cover illustration produced by Dr. Karl Harrison (Chemistry Department, University of Oxford).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200890287