Synthesis of Fe₃O₄@SiO₂@PMMA Core-Shell-Shell Magnetic Microspheres for Highly Efficient Enrichment of Peptides and Proteins for MALDI-ToF MS Analysis

Particularly enriching: Core–shell–shell Fe3O4§SiO2§PMMA composite microspheres (see picture; PMMA=poly(methyl methacrylate)) were synthesized readily by combining a sol‐gel approach with a seeded aqueous‐phase radical polymerization method. The microspheres were successfully applied toward the effe...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2010-01, Vol.49 (3), p.607-611
Main Authors: Chen, Hemei, Deng, Chunhui, Zhang, Xiangmin
Format: Article
Language:English
Subjects:
magnetic properties
microspheres
peptides
polymers
sol-gel processes
Online Access:Get full text
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Summary:Particularly enriching: Core–shell–shell Fe3O4§SiO2§PMMA composite microspheres (see picture; PMMA=poly(methyl methacrylate)) were synthesized readily by combining a sol‐gel approach with a seeded aqueous‐phase radical polymerization method. The microspheres were successfully applied toward the effective, rapid, and convenient enrichment of low‐concentration peptides and proteins for mass spectrometric analysis.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200904885