Intracellular pH‐Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics

Cut here to cure: Doxorubicin attached to pH‐sensitive mesoporous silica nanoparticles (MSN‐hydrazone‐Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH‐sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intr...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2010-10, Vol.49 (44), p.8214-8219
Main Authors: Lee, Chia‐Hung, Cheng, Shih‐Hsun, Huang, I‐Ping, Souris, Jeffrey S., Yang, Chung‐Shi, Mou, Chung‐Yuan, Lo, Leu‐Wei
Format: Article
Language:English
Subjects:
antitumor agents
apoptosis
controlled release
doxorubicin
mesoporous silica
Online Access:Get full text
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Summary:Cut here to cure: Doxorubicin attached to pH‐sensitive mesoporous silica nanoparticles (MSN‐hydrazone‐Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH‐sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201002639