Synthesis of Hexahydroindoles by Intramolecular C sp 3H Alkenylation: Application to the Synthesis of the Core of Aeruginosins

Give me five: Pd‐catalyzed intramolecular C sp 3H arylations have been successfully extended to alkenylations. This method shows remarkable selectivity and gives synthetically useful hexahydroindoles, as illustrated with the synthesis of the octahydroindole core of the aeruginosin family of natural...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-10, Vol.51 (41), p.10399-10402
Main Authors: Sofack-Kreutzer, Julien, Martin, Nicolas, Renaudat, Alice, Jazzar, Rodolphe, Baudoin, Olivier
Format: Article
Language:English
Subjects:
CC coupling
CH activation
natural products
nitrogen heterocycles
palladium
Online Access:Get full text
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Summary:Give me five: Pd‐catalyzed intramolecular C sp 3H arylations have been successfully extended to alkenylations. This method shows remarkable selectivity and gives synthetically useful hexahydroindoles, as illustrated with the synthesis of the octahydroindole core of the aeruginosin family of natural products (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201205403