Mixed metal MgO-ZrO2 nanoparticle-catalyzed O-tert-Boc protection of alcohols and phenols under solvent-free conditions

An environmentally benign method for O‐tert‐Boc protection of alcohols and phenols catalyzed by MgO–ZrO2 nanoparticles under solvent‐free conditions is described. A variety of phenols, alcohols (aliphatic and aromatic) were converted to corresponding O‐tert‐Boc products in good to excellent yield (5...

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Bibliographic Details
Published in:Applied organometallic chemistry 2012-08, Vol.26 (8), p.395-400
Main Authors: Gawande, Manoj B., Shelke, Sharad N., Branco, Paula S., Rathi, Anuj, Pandey, Rajesh K.
Format: Article
Language:English
Subjects:
mixed metal oxides
nanoparticles
O-tert-butoxycarbonylation
phenol and alcohol
reusable and recyclable
solvent-free
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Summary:An environmentally benign method for O‐tert‐Boc protection of alcohols and phenols catalyzed by MgO–ZrO2 nanoparticles under solvent‐free conditions is described. A variety of phenols, alcohols (aliphatic and aromatic) were converted to corresponding O‐tert‐Boc products in good to excellent yield (50–95%). The present protocol is expedient, simple, and efficient under solvent‐free conditions. The MgO–ZrO2 Nps are easily prepared from inexpensive precursors, and are reusable, recyclable and chemoselective. Copyright © 2012 John Wiley & Sons, Ltd.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.2846