Antibacterial Δ1-3-Ketosteroids from the South China Sea Gorgonian Coral Subergorgia rubra

Three new Δ1‐3‐ketosteroids characterized with a 9‐OH, subergosterones A–C (1–3), together with five known analogs 4–8, were obtained from the gorgonian coral Subergorgia rubra collected from the South China Sea. The structures of 1–3, including their absolute configurations, were determined by comp...

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Bibliographic Details
Published in:Chemistry & biodiversity 2015-07, Vol.12 (7), p.1068-1074
Main Authors: Sun, Xue-Ping, Cao, Fei, Shao, Chang-Lun, Wang, Mei, Zhang, Xiu-Li, Wang, Chang-Yun
Format: Article
Language:English
Subjects:
Antibacterial activity
Gorgonian
Subergorgia rubra
Subergosterones A - C
Δ1-3-Ketosteroid
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Summary:Three new Δ1‐3‐ketosteroids characterized with a 9‐OH, subergosterones A–C (1–3), together with five known analogs 4–8, were obtained from the gorgonian coral Subergorgia rubra collected from the South China Sea. The structures of 1–3, including their absolute configurations, were determined by comprehensive spectroscopic methods and electronic circular dichroism (ECD) experiments. Compounds 2 and 3 exhibited inhibitory antibacterial activities against Bacillus cereus with MIC values of 1.56 μM.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201400217