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Amphiphilic Bisporphyrin and Its YbIII Complex: Development of a Bifunctional Photodynamic Therapeutic and Near-Infrared Tumor-Imaging Agent

See and treat: An amphiphilic bisporphyrin and its YbIII complex Yb⋅1 are characterized by an appropriate hydrophobicity/hydrophilicity balance for membrane transport. Their cellular uptake by a rat tumor‐cell model is ten times higher than that of the parent tetracationic porphyrin, and their activ...

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Published in:Chembiochem : a European journal of chemical biology 2008-05, Vol.9 (7), p.1034-1039
Main Authors: Jiang, Feng-Lei, Poon, Chun-Ting, Wong, Wai-Kwok, Koon, Ho-Kee, Mak, Nai-Ki, Choi, Chun Yu, Kwong, Daniel W.J, Liu, Yi
Format: Article
Language:English
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Summary:See and treat: An amphiphilic bisporphyrin and its YbIII complex Yb⋅1 are characterized by an appropriate hydrophobicity/hydrophilicity balance for membrane transport. Their cellular uptake by a rat tumor‐cell model is ten times higher than that of the parent tetracationic porphyrin, and their activity as photodynamic therapeutics is correspondingly stronger. The near‐IR‐luminescence of Yb⋅1 is potentially useful for tumor imaging.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200700767