Amphiphilic Bisporphyrin and Its YbIII Complex: Development of a Bifunctional Photodynamic Therapeutic and Near-Infrared Tumor-Imaging Agent

See and treat: An amphiphilic bisporphyrin and its YbIII complex Yb⋅1 are characterized by an appropriate hydrophobicity/hydrophilicity balance for membrane transport. Their cellular uptake by a rat tumor‐cell model is ten times higher than that of the parent tetracationic porphyrin, and their activ...

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Published in:Chembiochem : a European journal of chemical biology 2008-05, Vol.9 (7), p.1034-1039
Main Authors: Jiang, Feng-Lei, Poon, Chun-Ting, Wong, Wai-Kwok, Koon, Ho-Kee, Mak, Nai-Ki, Choi, Chun Yu, Kwong, Daniel W.J, Liu, Yi
Format: Article
Language:English
Subjects:
amphiphiles
photodynamic therapeutics
porphyrinoids
tumor imaging
ytterbium
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container_issue 7
container_start_page 1034
container_title Chembiochem : a European journal of chemical biology
container_volume 9
creator Jiang, Feng-Lei
Poon, Chun-Ting
Wong, Wai-Kwok
Koon, Ho-Kee
Mak, Nai-Ki
Choi, Chun Yu
Kwong, Daniel W.J
Liu, Yi
description See and treat: An amphiphilic bisporphyrin and its YbIII complex Yb⋅1 are characterized by an appropriate hydrophobicity/hydrophilicity balance for membrane transport. Their cellular uptake by a rat tumor‐cell model is ten times higher than that of the parent tetracationic porphyrin, and their activity as photodynamic therapeutics is correspondingly stronger. The near‐IR‐luminescence of Yb⋅1 is potentially useful for tumor imaging.
doi_str_mv 10.1002/cbic.200700767
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subjects amphiphiles
photodynamic therapeutics
porphyrinoids
tumor imaging
ytterbium
title Amphiphilic Bisporphyrin and Its YbIII Complex: Development of a Bifunctional Photodynamic Therapeutic and Near-Infrared Tumor-Imaging Agent
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