Noncovalent Isotope Effect for Guest Encapsulation in Self‐Assembled Molecular Capsules

Deuteration leads to stronger binding: Deuterated guests bind within the confined space of the molecular capsule more preferentially than protiated guests (see scheme). The van 't Hoff analysis of the competitive association reveals that the preferential binding of the deuterated guests is driv...

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Bibliographic Details
Published in:Chemistry : a European journal 2009-12, Vol.15 (48), p.13286-13290
Main Authors: Haino, Takeharu, Fukuta, Katsunori, Iwamoto, Hajime, Iwata, Suehiro
Format: Article
Language:English
Subjects:
isotope effects
methyl internal rotation
molecular recognition
self‐assembly
van ’t Hoff plots
Online Access:Get full text
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Summary:Deuteration leads to stronger binding: Deuterated guests bind within the confined space of the molecular capsule more preferentially than protiated guests (see scheme). The van 't Hoff analysis of the competitive association reveals that the preferential binding of the deuterated guests is driven by enthalpy and opposed by entropy.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200902526