Front Cover: 1,3,9‐Triaza‐2‐oxophenoxazine: An Artificial Nucleobase Forming Highly Stable Self‐Base Pairs with Three AgI Ions in a Duplex (Chem. Eur. J. 31/2019)

Metal‐mediated base pairs (MMBPs) are expected to have wide applications in attractive fields such as DNA nanodevices and metal ion sensors. This work reports an artificial nucleobase, 1,3,9‐triaza‐2‐oxophenoxazine (9‐TAP), that could be used to design metal ion architectures and improve the conduct...

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Bibliographic Details
Published in:Chemistry : a European journal 2019-06, Vol.25 (31), p.7403-7403
Main Authors: Fujii, Akane, Nakagawa, Osamu, Kishimoto, Yuki, Okuda, Takumi, Nakatsuji, Yusuke, Nozaki, Natsumi, Kasahara, Yuuya, Obika, Satoshi
Format: Article
Language:English
Subjects:
artificial nucleobases
metal-mediated base pairs
oligonucleotides
phenoxazine
unnatural base pairs
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Summary:Metal‐mediated base pairs (MMBPs) are expected to have wide applications in attractive fields such as DNA nanodevices and metal ion sensors. This work reports an artificial nucleobase, 1,3,9‐triaza‐2‐oxophenoxazine (9‐TAP), that could be used to design metal ion architectures and improve the conductivity. Artificial nucleic acid with 9‐TAP was successfully synthesized and incorporated into oligodeoxyribonucleotides. As a result, self‐base pairs of 9‐TAP could form a highly stable MMBP with three AgI ions in a DNA duplex. Furthermore, such a MMBP was very stable even with three consecutive modifications in the duplex. More information can be found in the Communication by O. Nakagawa, S. Obika, et al. on page 7443.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201901481