Differences in clinical characteristics and disease‐free survival for Latino, African American, and non‐Latino white men with localized prostate cancer

• Published in: Cancer 2006-02, Vol.106 (4), p.789-795
• Main Authors: Latini, David M., Elkin, Eric P., Cooperberg, Matthew R., Sadetsky, Natalia, DuChane, Janeen, Carroll, Peter R.
• Format: Article
• Language: English
• Subjects: ethnicity; longitudinal analysis; prostatic neoplasms
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/cncr.21675

BACKGROUND Few studies of ethnicity and prostate cancer have included Latino men in analyses of baseline clinical characteristics, treatment selection, and disease‐free survival (DFS). The present study examines the impact of Latino ethnicity on these parameters in a large, multiinstitutional database of men with prostate cancer. METHODS We compared baseline disease characteristics and clinical outcomes for Latino (N = 138), non‐Latino White (NLW, N = 5619), and African‐American (AA, N = 608) men with localized prostate cancer by using chi‐square and ANOVA for baseline variables and survival analysis to examine differences in time to recurrence. RESULTS Latino men resembled AA men more than NLW on sociodemographic characteristics. AA men had higher Gleason scores and prostate‐specific antigen (PSA) at diagnosis than Latino or NLW men (both P < 0.01). 10% of both Latino and AA men presented with advanced disease (T3b/T4/N+/M+) versus 4% of NLW (P < 0.01). Latino men did not receive different treatments than NLW or AA men after controlling for clinical and demographic factors; however, AA men were more likely to receive external beam radiation (OR = 1.51, 95% confidence interval [CI] = 0.99–2.31) and hormone treatment (OR = 1.56, 95% CI = 1.05–2.32) then NLW men. For prostatectomy patients, 3‐year actuarial DFS rates were 83% for NLW men and 86% for Latino men versus 69% for AA men (P < 0.01). After controlling for clinical and sociodemographic variables, AA men were somewhat more likely than NLW to experience disease recurrence after radical prostatectomy (RP) (HR = 1.38, 95% CI = 0.98–1.94, P = 0.06). CONCLUSIONS Latinos are more similar to African Americans on sociodemographic characteristics but more similar to NLW on clinical presentation, treatments received, and DFS. Cancer 2006. © 2006 American Cancer Society. This study compared baseline disease characteristics and clinical outcomes for Latino, non‐Latino White, and African‐American men with localized prostate cancer. Latinos are more similar to African Americans on sociodemographic characteristics but more similar to non‐Latino Whites on clinical presentation and disease‐free survival rates. These results add new information to our understanding of the relation among ethnicity, sociodemographics, clinical characteristics, and outcomes of men with prostate cancer.