Completion of premaintenance phases in total therapies 2 and 3 improves clinical outcomes in multiple myeloma

• Published in: Cancer 2008-06, Vol.112 (12), p.2720-2725
• Main Authors: Barlogie, Bart, Haessler, Jeff, Pineda‐Roman, Mauricio, Anaissie, Elias, van Rhee, Frits, Kiwan, Elias, Steward, Douglas, Gurley, Jennifer, Jenkins, Bonnie, Crowley, John
• Format: Article
• Language: English
• Subjects: completion of therapy; event‐free survival; overall survival; total therapy
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/cncr.23487

BACKGROUND. Total Therapy (TT) programs are complex and their execution over the course of several years is fraught with patient attrition due to failure and toxicity of therapy and patient/physician acceptance. METHODS. The impact of completion versus noncompletion of intended treatment steps was examined in protocols TT2 (n = 668) and TT3 (n = 303) on overall survival (OS) and event‐free survival (EFS). RESULTS. By using appropriate landmarks of 36 months with TT2 and 18 months with TT3, representing the maxima to completion of premaintenance phases, postconsolidation OS was superior for 211 patients completing versus 311 patients not completing premaintenance steps on TT2 (P = .001), which also pertained to the 161 patients completing versus 47 not completing intended treatment steps on TT3 (P = .01). On multivariate analysis that included all patients, completion of therapy independently favored longer OS and EFS in the context of both standard prognostic factors and gene expression profiling‐defined risk; in addition, TT3 prolonged EFS over results obtained with TT2. CONCLUSIONS. 1) Completion of intended therapy was a significant independent variable conferring superior OS and EFS in TT programs; and 2) after adjusting for completion of therapy, EFS was still superior with TT3 versus TT2, supporting the beneficial role of bortezomib included in TT3. Collectively, these data point to the importance of designing clinical trials that balance the treatment requirements for disease control with host acceptance and tolerance. Cancer 2008. © 2008 American Cancer Society. The clinical impact of completion of premaintenance phases of Total Therapy 2 and 3 protocols for multiple myeloma was investigated using appropriate landmarks. The results revealed that compliance with intended therapies was an independent significant feature associated with prolongation of both event‐free and overall survival.