Oxidative Annulation of 3‐Aryl‐2H‐benzo[e][1,2,4]thiadiazine‐1,1‐dioxides with Aryl Aldehydes: An Easy Access to Hydroxyisoindolo[1,2‐b] benzothiadiazinedioxide Scaffolds

A novel and efficient approach has been developed for the synthesis of a diverse range of hydroxyisoindolo[1,2‐b]benzothiadiazinedioxide derivatives through a sequential palladium catalyzed cross‐dehydrogenative coupling (CDC) and intramolecular cyclization. This method works not only with aryl alde...

Full description

Saved in:
Bibliographic Details
Published in:European journal of organic chemistry 2020-02, Vol.2020 (8), p.923-931
Main Authors: Kumar, G. Ravi, Banik, Swarnayu, Ramesh, Boora, Sridhar, Balasubramanian, Venkata Subba Reddy, Basireddy
Format: Article
Language:English
Subjects:
Acylation
Aldehydes
Annulation
Benzyl alcohol
C–H activation
Palladium
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel and efficient approach has been developed for the synthesis of a diverse range of hydroxyisoindolo[1,2‐b]benzothiadiazinedioxide derivatives through a sequential palladium catalyzed cross‐dehydrogenative coupling (CDC) and intramolecular cyclization. This method works not only with aryl aldehydes and alcohols but also with toluene to generate angularly fused heterocycles in good to excellent yields. A novel strategy has been developed for the synthesis of hydroxyisoindolo[1,2‐b] benzothiadiazinedioxide derivatives through a sequential cross‐dehydrogenative coupling (CDC) and intramolecular annulation. This method works not only with aryl aldehydes and alcohols but also with toluene to produce annulated products.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201901509