Fabrication of NiSe2 decorated graphene oxide nanocomposite modified electrode as a high performance electrochemical sensor for carbamazepine

• Published in: Electroanalysis (New York, N.Y.) N.Y.), 2023-12, Vol.35 (12), p.n/a
• Main Authors: Agadi, Naveenkumar P., Tandel, Ranjita, Seetharamappa, Jaldappagari, Kalanur, Shankara
• Format: Article
• Language: English
• Subjects: carbamazepine; electrochemical sensor; graphene oxide; nickel selenide
• ISSN: 1040-0397; 1521-4109
• DOI: 10.1002/elan.202200574

Recently, semiconductor nanomaterials have gained interest amongst researchers because of their good electrocatalytic properties. Two dimensional (2D) transition metal dichalcogenide materials, NiSe2 have good physical, chemical, and transport properties for sensing applications. The present work demonstrates the fabrication of NiSe2‐graphene oxide (NiSe2−GO) modified glassy carbon electrode for the determination of carbamazepine (CBZ). The prepared nanocomposite was characterized by XRD, SEM and FT‐IR spectral methods. CBZ exhibited an irreversible oxidation peak at 0.85 V on NiSe2−GO/GCE in phosphate buffer of pH 7.0. A 54‐fold enhancement in oxidation peak current was observed at NiSe2−GO/GCE when compared to that at bare GCE. Sensing performance of NiSe2−GO/GCE was optimized by varying peak current dependent parameters. Linear relationship between the peak current and concentration of CBZ was observed in the range of 4.50×10−8–3.22×10−5 mol L−1 for differential pulse voltammetric method and 2.32×10−8–4.79×10−5 mol L−1 for square wave voltammetric method. The practical utility of the proposed sensor, was demonstrated by determining CBZ in pharmaceutical formulations and spiked urine samples.