A facile synthesis of pyrazolo[3,4-D]pyridazines Via the 1,3-dipolar cycloaddition of 3-arylsydnones. Synthesis and computational studies of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-D]pyridazine-3,6-diones and their 3,6-dichloro derivatives

The synthetic utility of 1,3‐dipolar cycloaddition of DMAD to sydnones has been exploited in the preparation of new 1‐aryl‐4,5‐dihydro‐1H‐pyrazolo[3,4‐d]pyridazine‐3,6‐diones 7a‐j and their aromatic 3,6‐dichloro analogues 8a‐j. The lactam‐lactim tautomerism of compound 7a has been studied by the sem...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2006-07, Vol.43 (4), p.827-834
Main Authors: Sanyal, R., Badami, Bharati V.
Format: Article
Language:English
Online Access:Get full text
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Summary:The synthetic utility of 1,3‐dipolar cycloaddition of DMAD to sydnones has been exploited in the preparation of new 1‐aryl‐4,5‐dihydro‐1H‐pyrazolo[3,4‐d]pyridazine‐3,6‐diones 7a‐j and their aromatic 3,6‐dichloro analogues 8a‐j. The lactam‐lactim tautomerism of compound 7a has been studied by the semi emperical (PM3) and ab initio methods.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570430403