Preservatives for Poliomyelitis (Salk) Vaccine III: 2-phenoxyethanol

Poliomyelitis vaccine contains antibiotics, but the antibiotics are inadequate for preventing the growth of heavy contamination with bacteria or light contamination with fungi. The addition of 0.375 per cent v/v of 2-phenoxyethanol to poliomyelitis vaccine furnished a stable mixture of preservatives...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1964-08, Vol.53 (8), p.899-901
Main Authors: Pivnick, Hilliard, Tracy, J.M., Tosoni, A.L., Glass, D.G.
Format: Article
Language:English
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Summary:Poliomyelitis vaccine contains antibiotics, but the antibiotics are inadequate for preventing the growth of heavy contamination with bacteria or light contamination with fungi. The addition of 0.375 per cent v/v of 2-phenoxyethanol to poliomyelitis vaccine furnished a stable mixture of preservatives (streptomycin, neomycin, and 2-phenoxyethanol) which was inhibitory to both bacteria and fungi. This mixture was also effective when poliomyelitis vaccine was mixed with diphtheria and tetanus toxoids and pertussis vaccine.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600530811