Ionic Liquid [HMIm]BF4 Mediated and Promoted Eco‐Friendly One‐Pot Sequential Synthesis of New Isoxazolyl Quinazolin‐4(3H)‐ones

1‐Methyl imidazolium tetraflouroborate ([HMIm]BF4) has been discovered to be an effective eco‐friendly solvent cum activator for a novel one‐pot sequential coupling and oxidative cyclization of 4‐amino‐3‐methyl‐5‐styrylisoxazoles, 2‐aminobenzoyl chloride and benzyl alcohols to produce new isoxazolyl...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2017-03, Vol.2 (9), p.2651-2654
Main Authors: Pittala, Praveen Kumar, Eligeti, Rajanarendar, Modugu, Nagi Reddy
Format: Article
Language:English
Subjects:
green chemistry
ionic liquid
isoxazolyl quinazolin-4(3H)-ones
one-pot synthesis
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Summary:1‐Methyl imidazolium tetraflouroborate ([HMIm]BF4) has been discovered to be an effective eco‐friendly solvent cum activator for a novel one‐pot sequential coupling and oxidative cyclization of 4‐amino‐3‐methyl‐5‐styrylisoxazoles, 2‐aminobenzoyl chloride and benzyl alcohols to produce new isoxazolyl quinazolin‐4(3H)‐ones under ambient conditions. The protocol proves to be an efficient and an environmentally benign in terms of high yields, low reaction times, ease of recovery, and reusability of reaction medium. A facile and convenient procedure for the synthesis of isoxazolyl quinazolin‐4(3H)‐ones from 4‐amino‐3‐methyl‐5‐styrylisoxazoles, 2‐aminobenzoyl chloride and benzyl alcohols using [HMIm]BF4 as task‐specific ionic liquid has been described. The important aspects of the present methodology are: short reaction time, good yields, large substrate scope, recyclable, and eco‐friendly solvent.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201700247