NaN3/NH4Cl‐Promoted Aza‐Cyclization: A Convenient Route for Bio‐Active Diverse Isoindolinone Derivatives

An efficient substrate dependent NaN3/NH4Cl promoted aza‐cyclization was developed via metal free cascade transformation. A wide variety of bicyclic/tricyclic isoindolinone derivative was achieved with excellent diastereoselectivity from achiral reagent system. This protocol also provided synthetic...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2018-11, Vol.3 (42), p.11950-11956
Main Authors: Ali, Sk Asraf, Bhaumik, Sanjay, Jana, Akash, Manna, Susanta Kumar, Ikbal, Mohammed, Mandal, Arabinda, Bera, Anirban, Jana, Avijit, Samanta, Shubhankar
Format: Article
Language:English
Subjects:
Aza-cyclization
Bio-imaging study
Diastereoselectivity
Dopamine D4 receptor
Isoindolinone
Online Access:Get full text
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Summary:An efficient substrate dependent NaN3/NH4Cl promoted aza‐cyclization was developed via metal free cascade transformation. A wide variety of bicyclic/tricyclic isoindolinone derivative was achieved with excellent diastereoselectivity from achiral reagent system. This protocol also provided synthetic route of dopamine D4 receptor in short way. The bio‐imaging study towards CHO cell line with our isoindolinone embedded new fluorophore was also demonstrated. An efficient substrate dependent NaN3/NH4Cl promoted aza‐cyclization was developed via metal free cascade transformation. A wide variety of bicyclic/tricyclic isoindolinone derivative was achieved with excellent diastereoselectivity from achiral reagent system. This protocol also provided synthetic route of dopamine D4 receptor in short way. The bio‐imaging study towards CHO cell line with our isoindolinone embedded new fluorophore was also demonstrated.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201802696