Microwave‐Assisted PEG‐400 Medaited Synthesis of 4,5‐dihydro‐1H‐benzo[g]indazole Derivatives: An Enaminone Approach

A simple, rapid and conceptually new efficient protocol for the synthesis of 4,5‐dihydro‐1H‐benzo[g]indazole derivatives from novel enaminones prepared via Blaise reaction under catalyst free conditions is reported involving polyethylene glycol (PEG‐400) as an efficient recyclable medium without usi...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2023-03, Vol.8 (12), p.n/a
Main Authors: Padder, Ashiq Hussain, Bhat, Mohammad Yaqoob, Prakash Rao, H. Surya, Gupta, Raman, Ahmed, Qazi Naveed
Format: Article
Language:English
Subjects:
3-amino enones
4,5-dihydro-1H-benzo[g]indazole
Microwave
PEG-400
Online Access:Get full text
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Summary:A simple, rapid and conceptually new efficient protocol for the synthesis of 4,5‐dihydro‐1H‐benzo[g]indazole derivatives from novel enaminones prepared via Blaise reaction under catalyst free conditions is reported involving polyethylene glycol (PEG‐400) as an efficient recyclable medium without using any organic co‐solvent or additive by Microwave irridation with 91–95 % yields without chromatography. An efficient method for the synthesis of different 4,5‐dihydro‐1H‐benzo[g]indazole derivatives from enaminones under catalyst free conditions is reported in polyethylene glycol (PEG‐400) by microwave irridation with 91–95 % yields.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202204951