β‐Cyclodextrin‐SO3H as a Supramolecular Catalyst for Efficient Greener Synthesis of Substituted Bis(6‐aminouracil‐5‐yl)methanes in Water

• Published in: ChemistrySelect (Weinheim) 2024-11, Vol.9 (42), p.n/a
• Main Authors: Gosavi, Swati D., Kale, Arun D., Dalal, Dipak S.
• Format: Article
• Language: English
• Subjects: 6‐Amino‐13‐dimethyluracil; Aromatic aldehydes; Bis(6‐aminouracil‐5‐yl)methanes; Water; β‐Cyclodextrin‐SO3H
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202404650

A simple, straightforward, and highly efficient greener approach for synthesizing bis(6‐aminouracil‐5‐yl)methane derivatives was developed by employing β‐cyclodextrin‐SO3H as supramolecular catalyst in water at 100 °C. A total of 16 bis(6‐aminouracil‐5‐yl)methanes were synthesized via a one‐pot reaction between substituted aromatic aldehydes, 6‐amino‐1,3‐dimethyluracil, and 10% β‐cyclodextrin‐SO3H in water with 84%–92% yield within 20–120 min. The salient features of this protocol included water as green solvent, β‐cyclodextrin‐SO3H as recyclable supramolecular catalyst, mild reaction conditions, easy isolation of pure products, and good to excellent yields. A simple and efficient green method for synthesis of bis(6‐aminouracil‐5‐yl)methanes has been developed using β‐cyclodextrin‐SO3H as a supramolecular catalyst in water at 100 °C. Total 16 compounds were synthesized in a one‐pot reaction with substituted aromatic aldehydes, 6‐amino‐1,3‐dimethyluracil, and β‐cyclodextrin‐SO3H (10%), achieving yields of 84%–92% in 20–120 min. This method features water as a green solvent, a recyclable catalyst, mild conditions, easy product isolation, and good to excellent yields.