Herrmananes A and B, two new sulfated hydrocarbons from the sea cumber Stichopus herrmanni

Using various chromatographic separations, two new sulfated hydrocarbons namely herrmananes A and B (1 and 2) were isolated from the aqueous fraction of the methanol residue of the sea cucumber Stichopus herrmanni. Their chemical structures were elucidated by extensive analysis of the 1D, 2D NMR and...

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Bibliographic Details
Published in:Vietnam journal of chemistry 2022-10, Vol.60 (5), p.685-687
Main Authors: Vien, Le Thi, Hanh, Tran Thi Hong, Quang, Tran Hong, Van Thanh, Nguyen, Cuong, Nguyen Xuan, Nam, Nguyen Hoai
Format: Article
Language:English
Subjects:
cytotoxic activity
Sea cucumber
Stichopus herrmanni
sulfated hydrocarbon
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Summary:Using various chromatographic separations, two new sulfated hydrocarbons namely herrmananes A and B (1 and 2) were isolated from the aqueous fraction of the methanol residue of the sea cucumber Stichopus herrmanni. Their chemical structures were elucidated by extensive analysis of the 1D, 2D NMR and HR‐QTOF mass spectra. In addition, compound 1 showed significant cytotoxicity on SK‐Mel‐2 cell line with IC50 value of 23.12 ± 1.87 μM, whereas 2 exhibited moderate effect on this cell line with IC50 value of 55.28 ± 4.17 μM.
ISSN:0866-7144
2572-8288
2572-8288
DOI:10.1002/vjch.202200095