Green synthesis of 2‐thioxo‐4‐quinazolinones from 2‐aminobenzamide and isothiocyanates

Novel green synthesis protocols of 2‐thioxo‐4‐quinazolinones starting from 2‐aminobenzamide and isothiocyanates have been reported. Method A: the reaction was carried out at 60 °C, in water, reaction time of 16 h. Method B: The reaction was carried out under solvent‐free conditions at 100 °C for 16 ...

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Bibliographic Details
Published in:Vietnam journal of chemistry 2024-05, Vol.62 (S1), p.147-152
Main Authors: Vo, Ngoc Binh, Nguyen, Le Thanh Hang, Tran, Thi Yen, Nguyen, Thi Thuy Hang, Nguyen, Le Anh, Ngo, Quoc Anh
Format: Article
Language:English
Subjects:
2‐aminobenzamide
2‐thioxoquinazolinones
green chemistry
isothiocyanates
quinazolinones
solvent‐free
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Summary:Novel green synthesis protocols of 2‐thioxo‐4‐quinazolinones starting from 2‐aminobenzamide and isothiocyanates have been reported. Method A: the reaction was carried out at 60 °C, in water, reaction time of 16 h. Method B: The reaction was carried out under solvent‐free conditions at 100 °C for 16 h. Based on these methods, six 2‐thixo‐4‐quinazolinone derivatives were synthesized with good yield. These methods have advantages, including no use of organic solvents, additives that avoid the generation of toxic waste, simple processes, cost‐effectiveness, good yields, ease of product isolation, and purification.
ISSN:0866-7144
2572-8288
2572-8288
DOI:10.1002/vjch.202300286