Evaluation of anti-bacterial activity of silver nanoparticles synthesised by coprophilous fungus PM0651419

The study explored biological synthesis of metallic silver nanoparticles (AgNPs) from the less explored non-pathogenic coprophilous fungus, sterile mycelium, PM0651419 and evaluates the antimicrobial efficacy of biosynthesised AgNPs when impregnated in wound fabrics and in combination with six antim...

Full description

Saved in:
Bibliographic Details
Published in:IET nanobiotechnology 2018-03, Vol.12 (2), p.106-115
Main Authors: Rangarajan, Sapna, Verekar, Shilpa, Deshmukh, Sunil Kumar, Bellare, Jayesh R, Balakrishnan, Arun, Sharma, Somesh, Vidya, Radhakrishnan, Chimote, Geetanjali
Format: Article
Language:English
Subjects:
antibacterial activity
antimicrobial efficacy
Bacillus subtilis
bacterial load
biological synthesis
biomedical materials
biosynthesised AgNPs
coprophilous fungus PM0651419
fabrics
Gram negative bacteria
Gram positive bacteria
metallic silver nanoparticles
microbiologically diverse battery
microorganisms
multidrug‐resistant bacteria
nanofabrication
nanomedicine
nanoparticles
nonpathogenic coprophilous fungus
pathogenic bacteria
polymicrobial wound infections
silver
Special Issue: 1st International Conference on Nanoscience and Nanotechnology (ICNAN 2016)
Staphylococcus aureus
sterile mycelium
wound dressings
wound fabrics
wounds
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The study explored biological synthesis of metallic silver nanoparticles (AgNPs) from the less explored non-pathogenic coprophilous fungus, sterile mycelium, PM0651419 and evaluates the antimicrobial efficacy of biosynthesised AgNPs when impregnated in wound fabrics and in combination with six antimicrobial agents. AgNPs alone proved to be potent antibacterial agents and in combination they enhanced the antibacterial activity and spectrum of antibacterials used in the study against a microbiologically diverse battery of Gram positive, Gram negative and multidrug-resistant bacteria. AgNPs impregnated on the wound dressings established their antibacterial activity by significantly reducing the bacterial load of pathogenic bacteria like Staphylococcus aureus and Bacillus subtilis establishing potential as effective antimicrobial wound dressings for treatment of polymicrobial wound infections. This study presents the first report on the potential of biosynthesis of AgNPs from the under explored class of coprophilous fungi. Their promise to be used in wound dressings and as potent antibacterials alone and in combination is evaluated
ISSN:1751-8741
1751-875X
1751-875X
DOI:10.1049/iet-nbt.2017.0037