Drug delivery system and in vitro release of luteolin based on magnetic nanocomposite (Fe3O4@ZIF-67)

To extend the wide application range of luteolin (LUT), a slow-release drug delivery system is urgently needed. In this work, Fe3O4@ZIF-67 was reported as the carrier of LUT. A facile synthesis method of Fe3O4@ZIF-67 was established with simply continuous stirring. The structure and function of the...

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Bibliographic Details
Published in:Micro & nano letters 2020-06, Vol.15 (7), p.425-429
Main Authors: Shi, Yuqiong, Qiu, Beibei, Wu, Xiangrong, Wang, Yuxuan, Zhu, Jinhua, Liu, Xiuhua, Zhao, Dongbao
Format: Article
Language:English
Subjects:
adsorption
adsorption kinetics
biomedical materials
Drug delivery systems
drugs
facile synthesis method
Fe3O4
Fourier transform infrared spectra
FTIR spectra
in vitro release
iron compounds
Iron oxides
Kinetic equations
LUT delivery system
luteolin
magnetic hysteresis
magnetic nanocomposite
maximum drug loading capacity
Nanocomposites
nanofabrication
nanomagnetics
nanomedicine
optimal reaction conditions
organometallic compounds
quasisecond‐order kinetic equation
Reaction kinetics
reaction rate constants
release mechanism
scanning electron microscopy
SEM
Sigmoidal model
simply continuous stirring
slow‐release drug delivery system
structural properties
TEM
TGA
thermal analysis
time 72.0 hour
transmission electron microscopy
vibrating sample magnetometer
XRD
X‐ray diffraction
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Summary:To extend the wide application range of luteolin (LUT), a slow-release drug delivery system is urgently needed. In this work, Fe3O4@ZIF-67 was reported as the carrier of LUT. A facile synthesis method of Fe3O4@ZIF-67 was established with simply continuous stirring. The structure and function of the nanocomposites were characterised by SEM, TEM, XRD, FTIR, VEM and TGA. Under the optimal reaction conditions, the maximum drug loading capacity of the carrier was obtained to be 308.07 µg/mg. And LUT was released about 55% from Fe3O4@ZIF-67 after 72 h. The adsorption kinetics and release kinetics of LUT were also investigated. The results showed that the relationship between time and drug loading fitted well with the quasi-second-order kinetic equation (R2 = 0.99) and the release mechanism followed the Sigmoidal model (R2 = 0.98). In short, Fe3O4@ZIF-67 could be developed as a carrier of the LUT delivery system for slow release.
ISSN:1750-0443
1750-0443
DOI:10.1049/mnl.2019.0671