Effects of exercise intensity and duration on a myokine, secreted protein acidic and rich in cysteine

Secreted protein acidic and rich in cysteine (SPARC), an exercise-induced myokine, has been suggested as a potential endogenous factor that suppresses colon tumorigenesis. However, the effects of different exercise protocols on circulating SPARC levels are unclear. The main purpose of this study was...

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Bibliographic Details
Published in:European journal of sport science 2022-09, Vol.22 (9), p.1401-1410
Main Authors: Miyamoto, Toshiaki, Shimizu, Yurika, Matsuo, Yuka, Otaru, Taiki, Kanzawa, Yuto, Miyamae, Nao, Yamada, Eri, Katsuno, Tomoyuki
Format: Article
Language:English
Subjects:
colon cancer
exercise
physical activity
Secreted protein acidic and rich in cysteine
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Summary:Secreted protein acidic and rich in cysteine (SPARC), an exercise-induced myokine, has been suggested as a potential endogenous factor that suppresses colon tumorigenesis. However, the effects of different exercise protocols on circulating SPARC levels are unclear. The main purpose of this study was to examine the effects of both exercise intensity and duration on circulating SPARC levels. This study also examined the relationship between responsiveness of SPARC levels and physical characteristics, including body composition and skeletal muscle function. Nineteen healthy adult men participated in four experimental interventions: two 30-min exercises at workloads corresponding to 60% (W60) and 40% (W40) peak oxygen uptake (VO 2peak ), a 45-min session of W40, and a 30-min session of complete rest. Blood SPARC and lactate concentrations were measured before and after each session. Only W60 significantly increased serum SPARC levels (p 
ISSN:1746-1391
1536-7290
DOI:10.1080/17461391.2021.1953152