COMPONENTS OF INJURY (HAEMORRHAGE AND TISSUE ISCHAEMIA) AFFECTING CARDIOVASCULAR REFLEXES IN MAN AND RAT

The effects of two components of tissue injury, namely fluid loss from the circulation and tissue ischaemia, on cardiovascular reflex activity have been studied. Moderate blood loss ( 10-20% blood volume) in the unanaesthetized rat increased the slope of the regression line relating heart period to...

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Bibliographic Details
Published in:Experimental physiology 1984-10, Vol.69 (4), p.753-762
Main Authors: Little, R. A., Randall, P. E., Stoner, H. B., Marshall, H. W., Redfern, W. S.
Format: Article
Language:English
Subjects:
Adult
Animals
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - drug effects
Blood Volume - drug effects
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Extremities - blood supply
Hemodynamics - drug effects
Hemorrhage - physiopathology
Humans
Ischemia - physiopathology
Male
Medical sciences
Middle Aged
Muscles - blood supply
Phenylephrine - pharmacology
Pressoreceptors - physiopathology
Pulse - drug effects
Rats
Rats, Inbred Strains
Reflex - drug effects
Valsalva Maneuver
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Summary:The effects of two components of tissue injury, namely fluid loss from the circulation and tissue ischaemia, on cardiovascular reflex activity have been studied. Moderate blood loss ( 10-20% blood volume) in the unanaesthetized rat increased the slope of the regression line relating heart period to mean arterial blood pressure and usually displaced it to the left (i.e. towards a relative bradycardia). A blood donation of 500 ml (approximately 10% blood volume) increased the Valsalva ratio in conscious man without a change in resting pulse rate. However, a 15 min period of unilateral limb ischaemia in man reduced the Valsalva ratio. The pattern of change in the pulse rat response to the Valsalva manoeuvre produced by limb ischaemia closely resembles that found previously after limb injury in man. There was no evidence that the endogenous opioids were involved in the interaction between limb ischaemia and cardiovascular reflex activity in man.
ISSN:0958-0670
0144-8757
1469-445X
DOI:10.1113/expphysiol.1984.sp002866