A COMPARISON OF CONTRACTILE FUNCTION IN LARGE AND SMALL PULMONARY ARTERIAL VESSELS OF THE RAT

The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smal...

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Bibliographic Details
Published in:Experimental physiology 1989-11, Vol.74 (6), p.947-950
Main Authors: Leach, Richard M., Twort, Charles H. C., Cameron, Ian R., Ward, Jeremy P. T.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood vessels and receptors
Fundamental and applied biological sciences. Psychology
Male
Muscle Contraction - drug effects
Muscle Contraction - physiology
Muscle, Smooth, Vascular - physiology
Pulmonary Artery - anatomy & histology
Pulmonary Artery - physiology
Rats
Serotonin - pharmacology
Vertebrates: cardiovascular system
Citations: Items that cite this one
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Summary:The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smaller (〈100-2000 µm) or larger (400-2000 µm). It is suggested that these vessels may play an important role in the generation of pulmonary vascular resistance.
ISSN:0958-0670
0144-8757
1469-445X
DOI:10.1113/expphysiol.1989.sp003366