A COMPARISON OF CONTRACTILE FUNCTION IN LARGE AND SMALL PULMONARY ARTERIAL VESSELS OF THE RAT

The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smal...

Full description

Saved in:
Bibliographic Details
Published in:Experimental physiology 1989-11, Vol.74 (6), p.947-950
Main Authors: Leach, Richard M., Twort, Charles H. C., Cameron, Ian R., Ward, Jeremy P. T.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood vessels and receptors
Fundamental and applied biological sciences. Psychology
Male
Muscle Contraction - drug effects
Muscle Contraction - physiology
Muscle, Smooth, Vascular - physiology
Pulmonary Artery - anatomy & histology
Pulmonary Artery - physiology
Rats
Serotonin - pharmacology
Vertebrates: cardiovascular system
Citations: Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4807-b0b8bb127dff8e3ed7c77617dfc520ddbf308cbcb5abc4d5af1b7f15bd75ca5e3
cites
container_end_page 950
container_issue 6
container_start_page 947
container_title Experimental physiology
container_volume 74
creator Leach, Richard M.
Twort, Charles H. C.
Cameron, Ian R.
Ward, Jeremy P. T.
description The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smaller (〈100-2000 µm) or larger (400-2000 µm). It is suggested that these vessels may play an important role in the generation of pulmonary vascular resistance.
doi_str_mv 10.1113/expphysiol.1989.sp003366
format article
fullrecord <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_wiley_primary_10_1113_expphysiol_1989_sp003366_EPH1989746947</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79375410</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4807-b0b8bb127dff8e3ed7c77617dfc520ddbf308cbcb5abc4d5af1b7f15bd75ca5e3</originalsourceid><addsrcrecordid>eNqNkcGO0zAQhi0EWsrCIyD5gLil2I0dJ0crpNtIaVIlKYIDsmzHoUHpJsRbLX17HFp2r5zsmfn-mfFvACBGS4yx_8n8HsfD2XZDv8RRGC3tiJDvB8ELsMAkiDxC6NeXYIEiGnooYOg1eGPtT4Swj0JyA25WNCIRIQvwncO42O54mVZFDou1i_K65HGdZglc73N3cfk0hxkv7xLI88-w2vIsg7t9ti1yXn6DvKyTMuUZ_JJUVZJVc5d6k8CS12_Bq1b21ry7nrdgv07qeONlxV0a88zTJETMU0iFSuEVa9o2NL5pmGYswC7UdIWaRrVuba20olJp0lDZYsVaTFXDqJbU-Lfg46XvOA2_TsY-iGNntel7eW-GkxUs8hklGDkwvIB6GqydTCvGqTvK6SwwErOz4tlZMTsr_jnrpO-vM07qaJon4dVKV_9wrUurZd9O8l539gkLGKXhXyy-YI9db87_PV4ku82cYO53CXt-8KH7cXjsJiMuKjvozjycBSMiEDP4BwAKofk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79375410</pqid></control><display><type>article</type><title>A COMPARISON OF CONTRACTILE FUNCTION IN LARGE AND SMALL PULMONARY ARTERIAL VESSELS OF THE RAT</title><source>Wiley Open Access</source><creator>Leach, Richard M. ; Twort, Charles H. C. ; Cameron, Ian R. ; Ward, Jeremy P. T.</creator><creatorcontrib>Leach, Richard M. ; Twort, Charles H. C. ; Cameron, Ian R. ; Ward, Jeremy P. T.</creatorcontrib><description>The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smaller (〈100-2000 µm) or larger (400-2000 µm). It is suggested that these vessels may play an important role in the generation of pulmonary vascular resistance.</description><identifier>ISSN: 0958-0670</identifier><identifier>ISSN: 0144-8757</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.1989.sp003366</identifier><identifier>PMID: 2594944</identifier><identifier>CODEN: QJEPD3</identifier><language>eng</language><publisher>Cambridge: The Physiological Society</publisher><subject>Animals ; Biological and medical sciences ; Blood vessels and receptors ; Fundamental and applied biological sciences. Psychology ; Male ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; Muscle, Smooth, Vascular - physiology ; Pulmonary Artery - anatomy &amp; histology ; Pulmonary Artery - physiology ; Rats ; Serotonin - pharmacology ; Vertebrates: cardiovascular system</subject><ispartof>Experimental physiology, 1989-11, Vol.74 (6), p.947-950</ispartof><rights>1989 The Physiological Society</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4807-b0b8bb127dff8e3ed7c77617dfc520ddbf308cbcb5abc4d5af1b7f15bd75ca5e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fexpphysiol.1989.sp003366$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fexpphysiol.1989.sp003366$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,11562,27924,27925,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1113%2Fexpphysiol.1989.sp003366$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=6755844$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2594944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leach, Richard M.</creatorcontrib><creatorcontrib>Twort, Charles H. C.</creatorcontrib><creatorcontrib>Cameron, Ian R.</creatorcontrib><creatorcontrib>Ward, Jeremy P. T.</creatorcontrib><title>A COMPARISON OF CONTRACTILE FUNCTION IN LARGE AND SMALL PULMONARY ARTERIAL VESSELS OF THE RAT</title><title>Experimental physiology</title><addtitle>Q J Exp Physiol</addtitle><description>The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smaller (〈100-2000 µm) or larger (400-2000 µm). It is suggested that these vessels may play an important role in the generation of pulmonary vascular resistance.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood vessels and receptors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>Pulmonary Artery - anatomy &amp; histology</subject><subject>Pulmonary Artery - physiology</subject><subject>Rats</subject><subject>Serotonin - pharmacology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0958-0670</issn><issn>0144-8757</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNqNkcGO0zAQhi0EWsrCIyD5gLil2I0dJ0crpNtIaVIlKYIDsmzHoUHpJsRbLX17HFp2r5zsmfn-mfFvACBGS4yx_8n8HsfD2XZDv8RRGC3tiJDvB8ELsMAkiDxC6NeXYIEiGnooYOg1eGPtT4Swj0JyA25WNCIRIQvwncO42O54mVZFDou1i_K65HGdZglc73N3cfk0hxkv7xLI88-w2vIsg7t9ti1yXn6DvKyTMuUZ_JJUVZJVc5d6k8CS12_Bq1b21ry7nrdgv07qeONlxV0a88zTJETMU0iFSuEVa9o2NL5pmGYswC7UdIWaRrVuba20olJp0lDZYsVaTFXDqJbU-Lfg46XvOA2_TsY-iGNntel7eW-GkxUs8hklGDkwvIB6GqydTCvGqTvK6SwwErOz4tlZMTsr_jnrpO-vM07qaJon4dVKV_9wrUurZd9O8l539gkLGKXhXyy-YI9db87_PV4ku82cYO53CXt-8KH7cXjsJiMuKjvozjycBSMiEDP4BwAKofk</recordid><startdate>19891112</startdate><enddate>19891112</enddate><creator>Leach, Richard M.</creator><creator>Twort, Charles H. C.</creator><creator>Cameron, Ian R.</creator><creator>Ward, Jeremy P. T.</creator><general>The Physiological Society</general><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19891112</creationdate><title>A COMPARISON OF CONTRACTILE FUNCTION IN LARGE AND SMALL PULMONARY ARTERIAL VESSELS OF THE RAT</title><author>Leach, Richard M. ; Twort, Charles H. C. ; Cameron, Ian R. ; Ward, Jeremy P. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4807-b0b8bb127dff8e3ed7c77617dfc520ddbf308cbcb5abc4d5af1b7f15bd75ca5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood vessels and receptors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>Pulmonary Artery - anatomy &amp; histology</topic><topic>Pulmonary Artery - physiology</topic><topic>Rats</topic><topic>Serotonin - pharmacology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leach, Richard M.</creatorcontrib><creatorcontrib>Twort, Charles H. C.</creatorcontrib><creatorcontrib>Cameron, Ian R.</creatorcontrib><creatorcontrib>Ward, Jeremy P. T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Leach, Richard M.</au><au>Twort, Charles H. C.</au><au>Cameron, Ian R.</au><au>Ward, Jeremy P. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A COMPARISON OF CONTRACTILE FUNCTION IN LARGE AND SMALL PULMONARY ARTERIAL VESSELS OF THE RAT</atitle><jtitle>Experimental physiology</jtitle><addtitle>Q J Exp Physiol</addtitle><date>1989-11-12</date><risdate>1989</risdate><volume>74</volume><issue>6</issue><spage>947</spage><epage>950</epage><pages>947-950</pages><issn>0958-0670</issn><issn>0144-8757</issn><eissn>1469-445X</eissn><coden>QJEPD3</coden><abstract>The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smaller (〈100-2000 µm) or larger (400-2000 µm). It is suggested that these vessels may play an important role in the generation of pulmonary vascular resistance.</abstract><cop>Cambridge</cop><pub>The Physiological Society</pub><pmid>2594944</pmid><doi>10.1113/expphysiol.1989.sp003366</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier ISSN: 0958-0670
ispartof Experimental physiology, 1989-11, Vol.74 (6), p.947-950
issn 0958-0670
0144-8757
1469-445X
language eng
recordid cdi_wiley_primary_10_1113_expphysiol_1989_sp003366_EPH1989746947
source Wiley Open Access
subjects Animals
Biological and medical sciences
Blood vessels and receptors
Fundamental and applied biological sciences. Psychology
Male
Muscle Contraction - drug effects
Muscle Contraction - physiology
Muscle, Smooth, Vascular - physiology
Pulmonary Artery - anatomy & histology
Pulmonary Artery - physiology
Rats
Serotonin - pharmacology
Vertebrates: cardiovascular system
title A COMPARISON OF CONTRACTILE FUNCTION IN LARGE AND SMALL PULMONARY ARTERIAL VESSELS OF THE RAT
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T21%3A09%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20COMPARISON%20OF%20CONTRACTILE%20FUNCTION%20IN%20LARGE%20AND%20SMALL%20PULMONARY%20ARTERIAL%20VESSELS%20OF%20THE%20RAT&rft.jtitle=Experimental%20physiology&rft.au=Leach,%20Richard%20M.&rft.date=1989-11-12&rft.volume=74&rft.issue=6&rft.spage=947&rft.epage=950&rft.pages=947-950&rft.issn=0958-0670&rft.eissn=1469-445X&rft.coden=QJEPD3&rft_id=info:doi/10.1113/expphysiol.1989.sp003366&rft_dat=%3Cproquest_24P%3E79375410%3C/proquest_24P%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4807-b0b8bb127dff8e3ed7c77617dfc520ddbf308cbcb5abc4d5af1b7f15bd75ca5e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=79375410&rft_id=info:pmid/2594944&rfr_iscdi=true