WE‐D‐L100J‐08: Application of Volumetric Molecular Breast Imaging with a Dedicated SPECT‐CT Mammotomograph

Purpose: Clinical 2D‐scintimammography therapeutic response monitoring results imply that fully‐3D molecular imaging could benefit early response prediction. Capabilities of prototype functional SPECT and anatomical x‐ray CT integrated imaging subsystems, dedicated to whole breast and chest wall dia...

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Bibliographic Details
Published in:Medical physics (Lancaster) 2007-06, Vol.34 (6), p.2597-2597
Main Authors: Tornai, M, Madhav, P, Crotty, D, Cutler, S, Perez, K, McKinley, R, Bowsher, J
Format: Article
Language:English
Subjects:
Cameras
Computed tomography
Cone beam computed tomography
Functional monitoring and imaging
Image registration
Medical diagnosis
Medical image reconstruction
Medical imaging
Single photon emission computed tomography
Therapeutics
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Summary:Purpose: Clinical 2D‐scintimammography therapeutic response monitoring results imply that fully‐3D molecular imaging could benefit early response prediction. Capabilities of prototype functional SPECT and anatomical x‐ray CT integrated imaging subsystems, dedicated to whole breast and chest wall diagnostic imaging of normalcy, disease and therapeutic response are demonstrated. The system provides patient comfort while imaging the pendant, uncompressed breast and anterior chest wall in common fields‐of‐view, yielding inherently registered, volumetric images. Method and Materials: The high‐performance SPECT system has 2.5mm CZT multi‐element pixelation and 6.7% FWHM energy resolution at 140keV; the subsystem gantry can sweep the camera about a hemisphere with simple/complex trajectories. The CT subsystem has 15% FWHM quasi‐monochromatic x‐ray cone beam at 36keV and 127micron CsI micro‐columnar pixelation. Both subsystems rotate on a common azimuthal stage. The CT system is equatorially restricted, though fully 3D positioning mobilization is possible for both subsystems on the same hybrid gantry. Emission SPECT data are iteratively reconstructed using OSEM, and transmission CT data using iterative OSTR. Rigid body transformations employing mixed emission/transmission fiducial markers around the breast help register and fuse the reconstructed data. Results: Initial cross contamination studies indicated transmission scatter contamination of SPECT images was negligible (
ISSN:0094-2405
2473-4209
DOI:10.1118/1.2761544