TH‐C‐217BCD‐01: Best in Physics (Imaging) ‐ Evaluation of Apoptosis and Proliferation in Non‐Thermal Pulsed HIFU Treated Mouse Prostate Tumors

Purpose: The underlying mechanism of non‐thermal effects of pulsed high intensity focused ultrasound (pFUS) on normal and tumor tissues is not well understood. Our recent studies showed significant prostate cancer cell killing in vitro and significant prostate tumor growth delay in vivo after pFUS t...

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Bibliographic Details
Published in:Medical Physics 2012-06, Vol.39 (6), p.4003-4003
Main Authors: Cvetkovic, D, Chen, X, Ma, C, Chen, L
Format: Article
Language:English
Subjects:
Cancer
Cell growth
DNA
Germanium
Image scanners
Medical imaging
Ultrasonic effects
Ultrasonography
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Summary:Purpose: The underlying mechanism of non‐thermal effects of pulsed high intensity focused ultrasound (pFUS) on normal and tumor tissues is not well understood. Our recent studies showed significant prostate cancer cell killing in vitro and significant prostate tumor growth delay in vivo after pFUS treatment. We hypothesized that these effects of non‐thermal pFUS are due to an increase in cell apoptosis and decrease in cell proliferation. Therefore, the purpose of this study was to analyze the biomarkers of apoptosis and proliferation in prostate tumors after pFUS exposures. Methods: An orthotopic prostate tumor model was established in nude mice. Prostate tumors were sonicated with MR guided pFUS (1MHz, 5W acoustic power, 5Hz frequency; 0.1duty cycle) for 60 sec for each sonication with temperature
ISSN:0094-2405
2473-4209
DOI:10.1118/1.4736330