Temperature monitoring of ultrasonically heated muscle with RARE chemical shift imaging

• Published in: Medical physics (Lancaster) 1997-12, Vol.24 (12), p.1899-1906
• Main Authors: Mulkern, Robert V., Chung, Andrew H., Jolesz, Ferenc A., Hynynen, Kullervo
• Format: Article
• Language: English
• Subjects: 87.52; 87.60.01; Animals; biomedical NMR; biomedical ultrasonics; Biothermics and thermal processes in biology; Body Temperature; chemical shift; Chemical shifts; Frequency measurement; Gels; hyperthermia; Hyperthermia, Induced; Image enhancement; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Medical imaging; muscle; Muscle, Skeletal - physiology; Muscles; patient monitoring; Phantoms, Imaging; Physicists; Rabbits; Silicones; Static and low‐frequency electric and magnetic fields effects; temperature measurement; Therapeutic applications; Ultrasonics; Ultrasonography; Water heating
• ISSN: 0094-2405; 2473-4209
• DOI: 10.1118/1.598103

The ability to monitor tissue temperature in ultrasonically heated rabbit muscle is demonstrated using a chemical shift imaging approach based on the rapid acquisition with relaxation enhancement (RARE) fast imaging method [Hennig et al., Magn. Reson. Med. 3, 823–833 (1986)] applied in a line scan format. A three echo sequence with a 16 Hz spectral resolution with 64 ms echo readouts and 78 ms echo spacings is shown capable of measuring relevantly small water frequency shifts in phantoms. Applied to the in vivo model of ultrasonically heated rabbit muscle, water resonance frequencies at the ultrasonic focal point were found to be linearly related to temperature with a slope of −0.007 ± 0.001 ppm/°C ( N=6 studies). Measurements of the frequency shift in unheated tissue located away from the ultrasonically heated tissue varied by approximately 0.011 ppm over the course of the experiments, leading to an estimated temperature accuracy of ±1.6 °C in vivo.