Effects of Ovariectomy and Estrogen Replacement Therapy on Laryngeal Tissue

Objective To determine the histopathological effect of estrogen deficiency and hormone replacement treatment on laryngeal tissue in ovariectomized rats. Study Design Animal study. Setting The study was conducted at the animal experiment laboratory of Marmara University School of Medicine, Istanbul,...

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Published in:Otolaryngology-head and neck surgery 2011-12, Vol.145 (6), p.987-991
Main Authors: Tatlıpınar, Arzu, Güneş, Pembegül, Özbeyli, Dilek, Çimen, Burak, Gökçeer, Tanju
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Language:English
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estrogen replacement
larynx
menopause
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container_end_page 991
container_issue 6
container_start_page 987
container_title Otolaryngology-head and neck surgery
container_volume 145
creator Tatlıpınar, Arzu
Güneş, Pembegül
Özbeyli, Dilek
Çimen, Burak
Gökçeer, Tanju
description Objective To determine the histopathological effect of estrogen deficiency and hormone replacement treatment on laryngeal tissue in ovariectomized rats. Study Design Animal study. Setting The study was conducted at the animal experiment laboratory of Marmara University School of Medicine, Istanbul, Turkey. Subjects and Methods Six‐month‐old female Wistar albino rats were divided into the following 3 groups (n = 8 per group): sham‐operated control, ovariectomized, and ovariectomized with estrogen replacement. Rats in the ovariectomized with estrogen replacement group received 17 β‐estradiol valerate (200 µg/kg, subcutaneously) once a week. Animals were killed after 8 weeks of intervention. Results Significant changes were observed in the ovariectomized group when edema in lamina propria, inflammation in squamous, respiratory epithelia and lamina propria, pseudostratification, and cilia loss were assessed. Except cilia loss, there were no significant differences in the assessments between the sham‐operated control and ovariectomized with estrogen replacement groups. Conclusions On the basis of histopathological evaluations, it was shown that estrogen replacement helped to improve laryngeal changes due to experimentally induced menopause.
doi_str_mv 10.1177/0194599811423638
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Study Design Animal study. Setting The study was conducted at the animal experiment laboratory of Marmara University School of Medicine, Istanbul, Turkey. Subjects and Methods Six‐month‐old female Wistar albino rats were divided into the following 3 groups (n = 8 per group): sham‐operated control, ovariectomized, and ovariectomized with estrogen replacement. Rats in the ovariectomized with estrogen replacement group received 17 β‐estradiol valerate (200 µg/kg, subcutaneously) once a week. Animals were killed after 8 weeks of intervention. Results Significant changes were observed in the ovariectomized group when edema in lamina propria, inflammation in squamous, respiratory epithelia and lamina propria, pseudostratification, and cilia loss were assessed. Except cilia loss, there were no significant differences in the assessments between the sham‐operated control and ovariectomized with estrogen replacement groups. 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subjects estrogen replacement
larynx
menopause
title Effects of Ovariectomy and Estrogen Replacement Therapy on Laryngeal Tissue
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