Morphological Changes Associated with Aging

:  Affymetrix gene‐expression analysis was performed on mRNAs from involved and noninvolved skin biopsies from three volunteers with Lentigo senilis. Of the 42,000 transcripts scanned, 17 were downregulated (1.9 times above the control level). A serine peptidase gene was downregulated in keeping wit...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2007-11, Vol.1119 (1), p.32-39
Main Authors: GOYARTS, EARL, MUIZZUDDIN, NEELAM, MAES, DANIEL, GIACOMONI, PAOLO U.
Format: Article
Language:English
Subjects:
age spots
gene expression
lentigo senilis
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Summary::  Affymetrix gene‐expression analysis was performed on mRNAs from involved and noninvolved skin biopsies from three volunteers with Lentigo senilis. Of the 42,000 transcripts scanned, 17 were downregulated (1.9 times above the control level). A serine peptidase gene was downregulated in keeping with the suggestion that age spots are associated with impaired melanin degradation. Three genes involved in the keratinization and synthesis and the organization of fibers in the basement membrane were downregulated, two metalloproteinase genes were upregulated, as were six genes associated with the inflammatory response, in keeping with the postulate that the visible aspects of aged skin are causally linked with a microinflammatory response. The regulation of five genes associated with the Wnt family was altered. Antiapoptotic genes were downregulated, and six genes associated with transmembrane transport were upregulated.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1404.006