Abstract 14070: Significant Correlation Between Coronary Fractional Flow Reserve and Dobutamine Stress Echocardiography in Patients With Moderate Coronary Artery Disease

IntroductionBoth the fractional flow reserve (FFR) measurement and the dobutamine stress echo (DSE) are accepted diagnostic methods to indicate revascularisation of a moderate coronary stenosis (CAS). The prospective comparative data of these two functional tests are limited for CAS in stable (SCAD)...

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Published in:Circulation (New York, N.Y.) N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A14070-A14070
Main Authors: Ahres, Abdelkrim, Jablonkai, Balázs, Rubóczky, Gábor, Oze, Ágnes, Szigeti, Zsolt, Nagybaczoni, Béla, Balogh, Zsuzsanna D, Apor, Astrid, Wohlfart, Karola, Andrássy, Peter
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container_issue Suppl_1 Suppl 1
container_start_page A14070
container_title Circulation (New York, N.Y.)
container_volume 134
creator Ahres, Abdelkrim
Jablonkai, Balázs
Rubóczky, Gábor
Oze, Ágnes
Szigeti, Zsolt
Nagybaczoni, Béla
Balogh, Zsuzsanna D
Apor, Astrid
Wohlfart, Karola
Andrássy, Peter
description IntroductionBoth the fractional flow reserve (FFR) measurement and the dobutamine stress echo (DSE) are accepted diagnostic methods to indicate revascularisation of a moderate coronary stenosis (CAS). The prospective comparative data of these two functional tests are limited for CAS in stable (SCAD) and bystander coronary artery disease. We sought to compare these tests in these clinical settings in a prospective study.MethodsPatients were included with CAS (30-70 % diameter) either with SCAD or bystander coronary artery disease revealed by coronary angiogram performed for ACS treatment. In this case the culprit vessel was excluded and the FFR study was deferred for a month. The FFR study was performed within 4 weeks of DSE. The target vessel considered abnormal if FFR was
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The prospective comparative data of these two functional tests are limited for CAS in stable (SCAD) and bystander coronary artery disease. We sought to compare these tests in these clinical settings in a prospective study.MethodsPatients were included with CAS (30-70 % diameter) either with SCAD or bystander coronary artery disease revealed by coronary angiogram performed for ACS treatment. In this case the culprit vessel was excluded and the FFR study was deferred for a month. The FFR study was performed within 4 weeks of DSE. The target vessel considered abnormal if FFR was &lt;0.8. The DSE was identified as positive if new wall motion abnormality was detected in ≥2 segments supplied by the target vessel. In the patient-based analysis FFR positive patients had at least one abnormal vessel, DSE positive patients had new wall motion abnormality in ≥2 segments.ResultsHundred and thirty-eight stenotic coronary arteries (91 LAD, 22 LCx and 25 RCA) were investigated in 111 patients (80 male, age60.7±0.88 years, ejection fraction 53.7±1.06%, bystander lesion in 30.4%). The sensitivity, specificity and concordance of DSE for detecting a vessel with FFR&lt;0.8 was 32.7 %, 89.9 % and 69.6 %, respectively (χ (1) =10.82, p&lt;0.001; Table). For detecting a patient with abnormal FFR the sensitivity, specificity and concordance of DSE was 37.2%, 86.7% and 67.5 % respectively (χ(1)=8.68, p=0.003; Table). The correlation between FFR and DSE was significant in both analysis (p&lt;0.001; p&lt;0.003; respectively).ConclusionOur prospective trial showed a significant correlation between DSE and FFR for the assessment of moderate coronary stenosis. The prognosis of patients with discordant functional tests should be evaluated to find out what is the optimal treatment strategy in these cases.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><language>eng</language><publisher>by the American College of Cardiology Foundation and the American Heart Association, Inc</publisher><ispartof>Circulation (New York, N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A14070-A14070</ispartof><rights>2016 by the American College of Cardiology Foundation and the American Heart Association, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Ahres, Abdelkrim</creatorcontrib><creatorcontrib>Jablonkai, Balázs</creatorcontrib><creatorcontrib>Rubóczky, Gábor</creatorcontrib><creatorcontrib>Oze, Ágnes</creatorcontrib><creatorcontrib>Szigeti, Zsolt</creatorcontrib><creatorcontrib>Nagybaczoni, Béla</creatorcontrib><creatorcontrib>Balogh, Zsuzsanna D</creatorcontrib><creatorcontrib>Apor, Astrid</creatorcontrib><creatorcontrib>Wohlfart, Karola</creatorcontrib><creatorcontrib>Andrássy, Peter</creatorcontrib><title>Abstract 14070: Significant Correlation Between Coronary Fractional Flow Reserve and Dobutamine Stress Echocardiography in Patients With Moderate Coronary Artery Disease</title><title>Circulation (New York, N.Y.)</title><description>IntroductionBoth the fractional flow reserve (FFR) measurement and the dobutamine stress echo (DSE) are accepted diagnostic methods to indicate revascularisation of a moderate coronary stenosis (CAS). The prospective comparative data of these two functional tests are limited for CAS in stable (SCAD) and bystander coronary artery disease. We sought to compare these tests in these clinical settings in a prospective study.MethodsPatients were included with CAS (30-70 % diameter) either with SCAD or bystander coronary artery disease revealed by coronary angiogram performed for ACS treatment. In this case the culprit vessel was excluded and the FFR study was deferred for a month. The FFR study was performed within 4 weeks of DSE. The target vessel considered abnormal if FFR was &lt;0.8. The DSE was identified as positive if new wall motion abnormality was detected in ≥2 segments supplied by the target vessel. In the patient-based analysis FFR positive patients had at least one abnormal vessel, DSE positive patients had new wall motion abnormality in ≥2 segments.ResultsHundred and thirty-eight stenotic coronary arteries (91 LAD, 22 LCx and 25 RCA) were investigated in 111 patients (80 male, age60.7±0.88 years, ejection fraction 53.7±1.06%, bystander lesion in 30.4%). The sensitivity, specificity and concordance of DSE for detecting a vessel with FFR&lt;0.8 was 32.7 %, 89.9 % and 69.6 %, respectively (χ (1) =10.82, p&lt;0.001; Table). For detecting a patient with abnormal FFR the sensitivity, specificity and concordance of DSE was 37.2%, 86.7% and 67.5 % respectively (χ(1)=8.68, p=0.003; Table). The correlation between FFR and DSE was significant in both analysis (p&lt;0.001; p&lt;0.003; respectively).ConclusionOur prospective trial showed a significant correlation between DSE and FFR for the assessment of moderate coronary stenosis. The prognosis of patients with discordant functional tests should be evaluated to find out what is the optimal treatment strategy in these cases.</description><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqdT8tKA0EQHETB9fEP_QMLs2_iLSZZvATECB5DZ7eTHR1nZLrjkk_yL52FgHf7UnR1VRd1oZKsysu0rIrZpUq01rO0KfL8Wt0wv8e1LpoqUT_zHUvATiArdaMfYGMOzuxNh05g4UMgi2K8g0eSkchNnHcYTtBOrnhBC631I7wQU_gmQNfD0u-Ogp_GEWwkEDOsusF3GHrjDwG_hhMYB8_xMzlheDMywNr3FFDoL2EehCIsDRMy3amrPVqm-zPeqrJdvS6e0tHbqOMPexwpbAdCK8M2FtSFzpo011mdTZNq3dRl8U_bL3V6aGU</recordid><startdate>20161111</startdate><enddate>20161111</enddate><creator>Ahres, Abdelkrim</creator><creator>Jablonkai, Balázs</creator><creator>Rubóczky, Gábor</creator><creator>Oze, Ágnes</creator><creator>Szigeti, Zsolt</creator><creator>Nagybaczoni, Béla</creator><creator>Balogh, Zsuzsanna D</creator><creator>Apor, Astrid</creator><creator>Wohlfart, Karola</creator><creator>Andrássy, Peter</creator><general>by the American College of Cardiology Foundation and the American Heart Association, Inc</general><scope/></search><sort><creationdate>20161111</creationdate><title>Abstract 14070: Significant Correlation Between Coronary Fractional Flow Reserve and Dobutamine Stress Echocardiography in Patients With Moderate Coronary Artery Disease</title><author>Ahres, Abdelkrim ; Jablonkai, Balázs ; Rubóczky, Gábor ; Oze, Ágnes ; Szigeti, Zsolt ; Nagybaczoni, Béla ; Balogh, Zsuzsanna D ; Apor, Astrid ; Wohlfart, Karola ; Andrássy, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wolterskluwer_health_00003017-201611111-007643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Ahres, Abdelkrim</creatorcontrib><creatorcontrib>Jablonkai, Balázs</creatorcontrib><creatorcontrib>Rubóczky, Gábor</creatorcontrib><creatorcontrib>Oze, Ágnes</creatorcontrib><creatorcontrib>Szigeti, Zsolt</creatorcontrib><creatorcontrib>Nagybaczoni, Béla</creatorcontrib><creatorcontrib>Balogh, Zsuzsanna D</creatorcontrib><creatorcontrib>Apor, Astrid</creatorcontrib><creatorcontrib>Wohlfart, Karola</creatorcontrib><creatorcontrib>Andrássy, Peter</creatorcontrib><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahres, Abdelkrim</au><au>Jablonkai, Balázs</au><au>Rubóczky, Gábor</au><au>Oze, Ágnes</au><au>Szigeti, Zsolt</au><au>Nagybaczoni, Béla</au><au>Balogh, Zsuzsanna D</au><au>Apor, Astrid</au><au>Wohlfart, Karola</au><au>Andrássy, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abstract 14070: Significant Correlation Between Coronary Fractional Flow Reserve and Dobutamine Stress Echocardiography in Patients With Moderate Coronary Artery Disease</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><date>2016-11-11</date><risdate>2016</risdate><volume>134</volume><issue>Suppl_1 Suppl 1</issue><spage>A14070</spage><epage>A14070</epage><pages>A14070-A14070</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>IntroductionBoth the fractional flow reserve (FFR) measurement and the dobutamine stress echo (DSE) are accepted diagnostic methods to indicate revascularisation of a moderate coronary stenosis (CAS). The prospective comparative data of these two functional tests are limited for CAS in stable (SCAD) and bystander coronary artery disease. We sought to compare these tests in these clinical settings in a prospective study.MethodsPatients were included with CAS (30-70 % diameter) either with SCAD or bystander coronary artery disease revealed by coronary angiogram performed for ACS treatment. In this case the culprit vessel was excluded and the FFR study was deferred for a month. The FFR study was performed within 4 weeks of DSE. The target vessel considered abnormal if FFR was &lt;0.8. The DSE was identified as positive if new wall motion abnormality was detected in ≥2 segments supplied by the target vessel. In the patient-based analysis FFR positive patients had at least one abnormal vessel, DSE positive patients had new wall motion abnormality in ≥2 segments.ResultsHundred and thirty-eight stenotic coronary arteries (91 LAD, 22 LCx and 25 RCA) were investigated in 111 patients (80 male, age60.7±0.88 years, ejection fraction 53.7±1.06%, bystander lesion in 30.4%). The sensitivity, specificity and concordance of DSE for detecting a vessel with FFR&lt;0.8 was 32.7 %, 89.9 % and 69.6 %, respectively (χ (1) =10.82, p&lt;0.001; Table). For detecting a patient with abnormal FFR the sensitivity, specificity and concordance of DSE was 37.2%, 86.7% and 67.5 % respectively (χ(1)=8.68, p=0.003; Table). The correlation between FFR and DSE was significant in both analysis (p&lt;0.001; p&lt;0.003; respectively).ConclusionOur prospective trial showed a significant correlation between DSE and FFR for the assessment of moderate coronary stenosis. The prognosis of patients with discordant functional tests should be evaluated to find out what is the optimal treatment strategy in these cases.</abstract><pub>by the American College of Cardiology Foundation and the American Heart Association, Inc</pub></addata></record>
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title Abstract 14070: Significant Correlation Between Coronary Fractional Flow Reserve and Dobutamine Stress Echocardiography in Patients With Moderate Coronary Artery Disease
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