Abstract 14474: Effect of Statin Therapy on Weight Loss and Diabetes in Bariatric Patients

• Published in: Circulation (New York, N.Y.) N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A14474-A14474
• Main Authors: Taylor, Beth A, Ng, Janet, Stone, Andrea, Tishler, Darren S, Papasavos, Pavlos, Thompson, Paul D
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539

IntroductionBariatric surgeries are considered effective treatments to achieve weight loss and improve diabetes control. Statins increase diabetes onset in clinical trials and many bariatric patients with metabolic disease are treated with statin therapy.HypothesisWe hypothesized that preoperative statin therapy would reduce the favorable effects of bariatric surgery on diabetes remission and weight loss.MethodsWe retrospectively examined the relationship of statin therapy to weight loss, diabetes mellitus onset and remission, and metabolic outcomes after bariatric surgery. The 1575 patients (1231 women) underwent laparoscopic adjustable gastric banding or LAGB (n=1035), Roux-en-Y gastric bypass or RYGB (n=468), and sleeve gastrectomies or SG (n=72) and were categorized as to statin use (n=671) and diabetes status (n=557) preoperatively and at one year follow-up.ResultsDiabetes resolved after surgery in 159 or 23.7% of patients on preoperative statins whereas 3 had new onset. Diabetes resolved in only 124 or 13.7% of patients not on preoperative statins with 4 new diabetes cases (χ = 26.1; p