Abstract 17201: P-selectin Level is Elevated in Patients With Non-valvular Atrial Fibrillation and With Spontaneous Echocardiographic Contrast

• Published in: Circulation (New York, N.Y.) N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A17201-A17201
• Main Authors: Cohoon, Kevin P, McBane, Robert D, Mazur, Matylda, Ammash, Naser M, Melduni, Rowlens M, Asirvatham, Samuel J, Wysokinski, Waldemar E
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539

BackgroundThe association of P-selectin, a biomarker of platelet activation, with thromboembolic complications in atrial fibrillation remains controversial. We tested the hypothesis that plasma soluble P-selectin (sP-selectin) level correlates with measures of left atrial blood stasis in this dysrhythmia.MethodsUsing a prospective case-control study design, plasma sP-selectin measured by solid-phase ELISA in 109 patients with non-valvular atrial fibrillation (NVAF; age 63±14 years; 26% women) and in 40 controls with normal sinus rhythm (NSR; age 64±14 years; 41% women) who were not on antiplatelet therapy was compared.ResultsThe median sP-selectin level was higher in NVAF cases compared to NSR controls [median (IQR) 26 (20-32) ng/ml vs 22 (15-29) ng/ml, p=.005]. While sP-selectin level did not significantly vary by left atrium volume index, left atrial appendage emptying velocity, it was associated with the higher intensity of spontaneous echocardiographic contrast (SEC; p=0.0042, see Figure).Mean sP-selectin level in NSR Control group, NVAF patients with spontaneous echocardiographic contrast (None, Mild, Moderate, Sever) and NVAF patients with left atrial appendage thrombus (LAAT) sP-selectin was significantly higher amongst patients with severe SEC compared to NSR controls (p