Abstract 17620: Incremental Values of Biomarkers for Predicting Incident Peripheral Vascular Disease Events in Patients With Established Coronary Artery Diseases

• Published in: Circulation (New York, N.Y.) N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A17620-A17620
• Main Authors: Wong, Yuen Kwun, Cheung, Chole Y, Au, Ka Wing, Hong, Sherry, Lee, Chi Ho, Hai, Jo Jo S, Lau, Kui Kai, Lam, Tai Hing, Sham, Pak Chung, Xu, Aimin, Lam, Karen S, Tse, Hung Fat
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539

BackgroundConventional clinical risk factors have modest sensitivity and specificity in predicting the occurrence of peripheral vascular disease (PVD). We sought to determine the role of different biomarkers, whether alone or in combination, exhibit incremental value for prediction of PVD.Methods and ResultsSerum adiponectin, adipocytes fatty acid binding protein 4 (A-FABP4), fibroblast growth factor (FGF)-19 and 21, lipocalcin-2 (LCN2) levels were measured in 1289 Chinese subjects with established coronary artery disease (CAD). After a median of 36.2 months follow-up, 15 patients (incidence, 2.5 per 1000 patient-years) developed new onset of symptomatic PVD requiring treatment. Among them, serum FGF-21, LCN2 and A-FABP4 provided better prediction than others with area under the receiver operating characteristic curves were 0.824 (95% CI, 0.728-0.920), 0.829 (95% CI, 0.730-0.927) and 0.826 (95% CI, 0.729-0.922) respectively after adjusting for clinical risk factors for PVD (all p