Abstract 18089: Shared Single Nucleotide Polymorphisms May Explain the Relationship Between Clusters of Comorbid Risk Factors and Incident Heart Failure in the Framingham Heart Study

IntroductionMultiple single nucleotide polymorphisms (SNPs) directly related to myocardial function have been implicated in congestive heart failure (CHF). Polymorphisms related to non-cardiac risk factors for CHF remain incompletely described.HypothesisCHF risk factors reflect shared genetic determ...

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Published in:Circulation (New York, N.Y.) N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A18089-A18089
Main Authors: Stevens, Laura, Hinterberg, Michael A, Goerg, Carsten, Kao, David P
Format: Article
Language:English
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Summary:IntroductionMultiple single nucleotide polymorphisms (SNPs) directly related to myocardial function have been implicated in congestive heart failure (CHF). Polymorphisms related to non-cardiac risk factors for CHF remain incompletely described.HypothesisCHF risk factors reflect shared genetic determinants with CHF.MethodsParticipants from the Framingham Heart Study Original and Offspring cohorts underwent genotyping using the Affymetrix GeneChip Human Mapping 100k set. In total 1345 subjects were included in this analysis. Incident heart failure was defined as any hospitalization or history of clinical CHF during routine exam visits that was not present at baseline. Family-based association testing (FBAT) was performed to identify SNPs associated with incident CHF. SNPs with an FBAT p-value
ISSN:0009-7322
1524-4539