Abstract 15126: Local Epicardial Application of Amiodarone-Releasing Hydrogel: Experimental and Clinical Study Results

• Published in: Circulation (New York, N.Y.) N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A15126-A15126
• Main Authors: Bockeria, Olga, Kanametov, Teymuraz, Kudzoeva, Zalina, Bockeria, Leo
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539

Introductionatrial fibrillation after open heart surgery remains the one of most frequent complication, which increase hospitalization stay and postoperative mortality. Local epicardial amiodarone application has been recognized as a promising method in preventing the postoperative atrial fibrillation.HypothesisTo evaluate the safety and efficacy of the local epicardial application of the hydrogel with amiodarone in the preclinical setting; to determine the optimal dose of amiodarone; to provision the definition, design and preliminary results of amiodarone-releasing hydrogel usage in the clinical practice.MethodsEpicardial application of amiodarone-releasing hydrogel performed on 46 rabbits (3-5 kg) who were divided into 5 groups according to the dose of amiodarone in hydrogelGroup 1 - 1 mg; Group 2 - 3 mg; Group 3 - 6 mg; Group 4 - 0 mg; Group 5 - IV infusion of 60 mg of amiodarone. Invasive measurement of blood pressure, continuous heart rate monitoring of ECG and laboratory parameters for inflammation were assessed. Pathomorphology of the heart was examined in 5 rabbits from each group derived from the experiment consecutively on the 3-rd, 7-th and 14-th days.ResultsNo systemic inflammatory response following the application of the amiodarone-releasing hydrogel, neither the significant change in the WBC level before and after the application (p = 0.735) was detected. No signs of inflammatory response and postoperative adhesions were observed on pathology exam. Group 2 demonstrated a significant reduction in the heart rate158 ± 16 before versus 130 ± 11 and after the application (p