Abstract 15629: Combinations of Mitral Annulus and Aortic Valve Calcifications Detected by Echocardiography Predict the Severity of Coronary Artery Calcification and Reflect Systemic Inflammation

IntroductionCoronary artery calcification is a risk for coronary vascular event. Mitral annular calcification (MAC) as well as aortic valve calcification (AVC) is closely associated with coronary artery calcification. Progression of these calcifications are supposed to be mediated by systemic inflam...

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Published in:Circulation (New York, N.Y.) N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A15629-A15629
Main Authors: Nishida, Hiroki, Abe, Haruhiko, Fukushima, Takashi, Horiuchi, Kohei, Nakamura, Masayuki, Ohashi, Takuya, Iida, Yoshinori, Toriyama, Chieko, Kosugi, Shumpei, Ozaki, Tatsuhisa, Kato, Taishi, Shinouchi, Kazuya, Mishima, Tsuyoshi, Awata, Masaki, Date, Motoo, Ueda, Yasunori, Uematsu, Masaaki, Koretsune, Yukihiro
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Language:English
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Summary:IntroductionCoronary artery calcification is a risk for coronary vascular event. Mitral annular calcification (MAC) as well as aortic valve calcification (AVC) is closely associated with coronary artery calcification. Progression of these calcifications are supposed to be mediated by systemic inflammation. The purpose of this study was to investigate if the combinations of MAC and AVC detected by transthoracic echocardiography (TTE) are useful for predicting the severity of coronary artery calcification and relate to systemic inflammation.MethodsWe enrolled 336 consecutive patients who underwent both TTE and multidetector computed tomography (MDCT) in our hospital from January to December 2016. Systemic inflammation was evaluated by serum C-reactive protein level. Patients with post cardiac surgery, infectious endocarditis, and unsatisfactory TTE images were excluded. Patients were classified into three groups based on the presence or absence of MAC and/or AVC detected by TTEgroup A (neither MAC nor AVC was present), group B (either MAC or AVC), and group C (both MAC and AVC). Coronary artery calcification was investigated using Agatston score with MDCT.ResultsPatient age was 67±12 years. TTE detected MAC in 72 patients (21%) and AVC in 160 patients (48%). Group A comprised 164 patients (49%); group B, 112 patients (30%); Group C, 60 patients (18%). Agatston score increased significantly from group A to group B (P
ISSN:0009-7322
1524-4539