Abstract 9828: Cardiovascular Adaptations in Chronic Mixed Aortic Valve Disease: Increase in Valve Gradients, but Little Left Ventricular Dilatation Over Time

• Published in: Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A9828-A9828
• Main Authors: Isaza, Nicolas, Desai, Milind Y, Kapadia, Samir R, Krishnaswamy, Amar, Rodriguez, L Leonardo, Grimm, Richard A, Conic, Julijana, Rosselli, Eric E, Gillinov, Marc, Johnston, Douglas R, Svensson, Lars G, Griffin, Brian P, Popovic, Zoran B
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.9828

IntroductionAs opposed to isolated aortic stenosis (AS) and regurgitation (AR), the natural history of mixed aortic valve disease (MAVD) is unclear. In this study, we evaluated the cardiovascular adaptations to chronic MAVD.HypothesisThe progression of structural and hemodynamic echocardiographic parameters in MAVD differs from the patterns observed in isolated AS or AR.MethodsThis observational cohort study included 862 adult patients with preserved LVEF and at least moderate AR and AS evaluated between January 2003 and December 2013. Echocardiographic parameters were analyzed using longitudinal data analysis in patients who did not have surgery and survived for more than two years, and in those who had aortic valve replacement (AVR) after at least two years follow-up.ResultsCompared to those who were conservatively managed, those who underwent AVR had higher initial AV peak gradients (p