Abstract 12199: Diagnostic Utility And Pathogenic Role of Circulating Micrornas in Vasospastic Angina

• Published in: Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A12199-A12199
• Main Authors: Park, Chan Soon, Kim, Inho, Oh, Gyu Chul, Han, Jung-Kyu, Yang, Han-Mo, Park, Kyung Woo, Cho, Hyun-Jai, Kang, Hyun-Jae, Koo, Bon-Kwon, Chung, Woo-Young, Oh, Seil, Lee, Hae-Young
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.12199

IntroductionVasospastic angina (VA) is often overlooked and difficult to diagnose non-invasively. Furthermore, though endothelial dysfunction and smooth muscle hyperactivity are suggested as main causes, there is still a demand to investigate the pathogenesis of VA.HypothesisHerein, we investigated the diagnostic value and pathophysiological role of circulating microRNA (miR) in patients with VA.MethodsWe enrolled patients who underwent coronary angiography (CAG) for chest pain from 2013 to 2016 at Seoul National University Hospital. Blood samples were obtained during the CAG to assess the levels of miR-17-5p, miR-92a-3p, miR-126-3p, miR-145-5p, miR-221-3p, and miR-222-3p. We also explored the role of miR regarding endothelial nitric oxide synthase (eNOS) in human coronary artery endothelial cells (hCAECs).ResultsAmong 121 patients, 46 were diagnosed as VA, 26 as insignificant coronary lesion (ICL), and 49 as atherothrombotic angina. Patients with VA showed significantly higher expression of miR-17-5p, miR-92a-3p, and miR-126-3p compared to patients with ICL. The miR expression profiles were generally independent to conventional cardiovascular risk factors. miR Scores based on the levels of six miRs were able to discriminate the patients with VA from those with ICL (area under the curve=0.756, P