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Abstract 13439: Detection of Atrial Fibrillation With a Portable Device During Cardiovascular Disease Screening in Primary Care: Data From the PROVAR + Study

IntroductionAtrial fibrillation (AF) is the most common arrhythmia and is associated with significant morbidity. Portable devices such as MyDiagnostick® (MDS) allow for AF screening. We aimed to evaluate the sensitivity and specificity of MDS for AF diagnosis in patients in the waiting list for echo...

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Published in:Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A13439-A13439
Main Authors: Diamantino, Adriana C, Nascimento, Bruno R, Beaton, Andrea Z, Nunes, Maria Do Carmo P, Oliveira, Kaciane K, Rabelo, Lara C, Barbosa, Marcia, Reese, Alison T, Olivieri, Laura, Mata, Mariana D, Rios, João Pedro P, Pereira, Augusto F, Diamantino, Luciana C, Ribeiro, Antonio L, Sable, Craig A, Brant, Luisa C
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container_end_page A13439
container_issue Suppl_1 Suppl 1
container_start_page A13439
container_title Circulation (New York, N.Y.)
container_volume 140
creator Diamantino, Adriana C
Nascimento, Bruno R
Beaton, Andrea Z
Nunes, Maria Do Carmo P
Oliveira, Kaciane K
Rabelo, Lara C
Barbosa, Marcia
Reese, Alison T
Olivieri, Laura
Mata, Mariana D
Rios, João Pedro P
Pereira, Augusto F
Diamantino, Luciana C
Ribeiro, Antonio L
Sable, Craig A
Brant, Luisa C
description IntroductionAtrial fibrillation (AF) is the most common arrhythmia and is associated with significant morbidity. Portable devices such as MyDiagnostick® (MDS) allow for AF screening. We aimed to evaluate the sensitivity and specificity of MDS for AF diagnosis in patients in the waiting list for echocardiogram (ECHO) in primary care and to assess the prevalence of AF by this method.MethodsIn 5 days, 1,518 patients from low-income areas of Brazil underwent clinical evaluation and cardiovascular (CV) risk stratification using a study-derived score based on demographics and CV comorbidities. Patients were then screened for AF with MDS, holding the device with both hands for 1-minute. The test was considered positive when the device indicated the presence of AF. The gold-standard for AF diagnosis was the 12-lead ECG interpreted by a cardiologist. Patients with intermediate CV risk were submitted to ECHO screening with ultraportable device. Individuals with abnormalities in screening or those with high CV risk, in addition to a low-risk sample, underwent standard ECHO. Major heart disease (HD) was defined as moderate to severe valve disease, ventricular dysfunction/hypertrophy, pericardial effusion or wall-motion abnormalities.ResultsMean age was 58 ± 16 years, 66% were women. Prevalence of AF by MDS was 6.4% (N=97)higher in patients with high CV risk (12.6%), compared with moderate (6.1%) and low risk (2.2 %), p65-year-olds (9.3%) than in those aged 40-64 years (4.2%) and
doi_str_mv 10.1161/circ.140.suppl_1.13439
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Portable devices such as MyDiagnostick® (MDS) allow for AF screening. We aimed to evaluate the sensitivity and specificity of MDS for AF diagnosis in patients in the waiting list for echocardiogram (ECHO) in primary care and to assess the prevalence of AF by this method.MethodsIn 5 days, 1,518 patients from low-income areas of Brazil underwent clinical evaluation and cardiovascular (CV) risk stratification using a study-derived score based on demographics and CV comorbidities. Patients were then screened for AF with MDS, holding the device with both hands for 1-minute. The test was considered positive when the device indicated the presence of AF. The gold-standard for AF diagnosis was the 12-lead ECG interpreted by a cardiologist. Patients with intermediate CV risk were submitted to ECHO screening with ultraportable device. Individuals with abnormalities in screening or those with high CV risk, in addition to a low-risk sample, underwent standard ECHO. Major heart disease (HD) was defined as moderate to severe valve disease, ventricular dysfunction/hypertrophy, pericardial effusion or wall-motion abnormalities.ResultsMean age was 58 ± 16 years, 66% were women. Prevalence of AF by MDS was 6.4% (N=97)higher in patients with high CV risk (12.6%), compared with moderate (6.1%) and low risk (2.2 %), p&lt;0.001. Prevalence was also higher in &gt;65-year-olds (9.3%) than in those aged 40-64 years (4.2%) and &lt;40 years (6.9%), p=0.001. Of 1,063 patients undergoing ECHO screening, 45% (N=481) had HD, whereas among 64 patients with AF in MDS undergoing ECHO, 55% had HD (p=0.12). Positive AF screening was independently associated with the presence of HD on standard ECHO (OR = 3.9, 95%CI 2.1 - 7.2, p &lt;0.001) after adjusting for sex, age and clinical variables. Compared to the ECG, the MDS had sensitivity of 97% (95%CI 86 - 100) and specificity of 69% (95%CI 61 - 76.) for AF detection.ConclusionScreening with the MDS portable device demonstrated high sensitivity for early detection of AF in primary care. Prevalence in a population referred for ECHO was high and associated with age and higher CV risk. AF at screening was independently associated with HD detected by ECHO.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/circ.140.suppl_1.13439</identifier><language>eng</language><publisher>by the American College of Cardiology Foundation and the American Heart Association, Inc</publisher><ispartof>Circulation (New York, N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A13439-A13439</ispartof><rights>2019 by the American College of Cardiology Foundation and the American Heart Association, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Diamantino, Adriana C</creatorcontrib><creatorcontrib>Nascimento, Bruno R</creatorcontrib><creatorcontrib>Beaton, Andrea Z</creatorcontrib><creatorcontrib>Nunes, Maria Do Carmo P</creatorcontrib><creatorcontrib>Oliveira, Kaciane K</creatorcontrib><creatorcontrib>Rabelo, Lara C</creatorcontrib><creatorcontrib>Barbosa, Marcia</creatorcontrib><creatorcontrib>Reese, Alison T</creatorcontrib><creatorcontrib>Olivieri, Laura</creatorcontrib><creatorcontrib>Mata, Mariana D</creatorcontrib><creatorcontrib>Rios, João Pedro P</creatorcontrib><creatorcontrib>Pereira, Augusto F</creatorcontrib><creatorcontrib>Diamantino, Luciana C</creatorcontrib><creatorcontrib>Ribeiro, Antonio L</creatorcontrib><creatorcontrib>Sable, Craig A</creatorcontrib><creatorcontrib>Brant, Luisa C</creatorcontrib><title>Abstract 13439: Detection of Atrial Fibrillation With a Portable Device During Cardiovascular Disease Screening in Primary Care: Data From the PROVAR + Study</title><title>Circulation (New York, N.Y.)</title><description>IntroductionAtrial fibrillation (AF) is the most common arrhythmia and is associated with significant morbidity. Portable devices such as MyDiagnostick® (MDS) allow for AF screening. We aimed to evaluate the sensitivity and specificity of MDS for AF diagnosis in patients in the waiting list for echocardiogram (ECHO) in primary care and to assess the prevalence of AF by this method.MethodsIn 5 days, 1,518 patients from low-income areas of Brazil underwent clinical evaluation and cardiovascular (CV) risk stratification using a study-derived score based on demographics and CV comorbidities. Patients were then screened for AF with MDS, holding the device with both hands for 1-minute. The test was considered positive when the device indicated the presence of AF. The gold-standard for AF diagnosis was the 12-lead ECG interpreted by a cardiologist. Patients with intermediate CV risk were submitted to ECHO screening with ultraportable device. Individuals with abnormalities in screening or those with high CV risk, in addition to a low-risk sample, underwent standard ECHO. Major heart disease (HD) was defined as moderate to severe valve disease, ventricular dysfunction/hypertrophy, pericardial effusion or wall-motion abnormalities.ResultsMean age was 58 ± 16 years, 66% were women. Prevalence of AF by MDS was 6.4% (N=97)higher in patients with high CV risk (12.6%), compared with moderate (6.1%) and low risk (2.2 %), p&lt;0.001. Prevalence was also higher in &gt;65-year-olds (9.3%) than in those aged 40-64 years (4.2%) and &lt;40 years (6.9%), p=0.001. Of 1,063 patients undergoing ECHO screening, 45% (N=481) had HD, whereas among 64 patients with AF in MDS undergoing ECHO, 55% had HD (p=0.12). Positive AF screening was independently associated with the presence of HD on standard ECHO (OR = 3.9, 95%CI 2.1 - 7.2, p &lt;0.001) after adjusting for sex, age and clinical variables. Compared to the ECG, the MDS had sensitivity of 97% (95%CI 86 - 100) and specificity of 69% (95%CI 61 - 76.) for AF detection.ConclusionScreening with the MDS portable device demonstrated high sensitivity for early detection of AF in primary care. Prevalence in a population referred for ECHO was high and associated with age and higher CV risk. AF at screening was independently associated with HD detected by ECHO.</description><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqdj91OwkAQhTdGE_HnFczcm9bdbktT7whIuLMBo5dkWAa7urRkdgvhYXxXF-ITeDE5Zybny8kI8aBkqtRQPRnLJlW5TH2_27mlSpXOdXUhBqrI8iQvdHUpBlLKKil1ll2LG--_4jrUZTEQP6OVD4wmwJl6hgkFMsF2LXQbGAW26GBqV2ydw_P5w4YGEOqOA64cRWBvTZSebfsJY-S17fboTe-QYWI9oSdYGCZqTwHbQs12i3w8ZSkWYkCYcreF0BDU89f30RweYRH69fFOXG3Qebr_01uRT1_exrPk0LlA7L9dfyBeNoQuNMv4lNRSlUkmVaVUnCSarNT_xH4BEUppaw</recordid><startdate>20191119</startdate><enddate>20191119</enddate><creator>Diamantino, Adriana C</creator><creator>Nascimento, Bruno R</creator><creator>Beaton, Andrea Z</creator><creator>Nunes, Maria Do Carmo P</creator><creator>Oliveira, Kaciane K</creator><creator>Rabelo, Lara C</creator><creator>Barbosa, Marcia</creator><creator>Reese, Alison T</creator><creator>Olivieri, Laura</creator><creator>Mata, Mariana D</creator><creator>Rios, João Pedro P</creator><creator>Pereira, Augusto F</creator><creator>Diamantino, Luciana C</creator><creator>Ribeiro, Antonio L</creator><creator>Sable, Craig A</creator><creator>Brant, Luisa C</creator><general>by the American College of Cardiology Foundation and the American Heart Association, Inc</general><scope/></search><sort><creationdate>20191119</creationdate><title>Abstract 13439: Detection of Atrial Fibrillation With a Portable Device During Cardiovascular Disease Screening in Primary Care: Data From the PROVAR + Study</title><author>Diamantino, Adriana C ; Nascimento, Bruno R ; Beaton, Andrea Z ; Nunes, Maria Do Carmo P ; Oliveira, Kaciane K ; Rabelo, Lara C ; Barbosa, Marcia ; Reese, Alison T ; Olivieri, Laura ; Mata, Mariana D ; Rios, João Pedro P ; Pereira, Augusto F ; Diamantino, Luciana C ; Ribeiro, Antonio L ; Sable, Craig A ; Brant, Luisa C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wolterskluwer_health_00003017-201911191-019273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Diamantino, Adriana C</creatorcontrib><creatorcontrib>Nascimento, Bruno R</creatorcontrib><creatorcontrib>Beaton, Andrea Z</creatorcontrib><creatorcontrib>Nunes, Maria Do Carmo P</creatorcontrib><creatorcontrib>Oliveira, Kaciane K</creatorcontrib><creatorcontrib>Rabelo, Lara C</creatorcontrib><creatorcontrib>Barbosa, Marcia</creatorcontrib><creatorcontrib>Reese, Alison T</creatorcontrib><creatorcontrib>Olivieri, Laura</creatorcontrib><creatorcontrib>Mata, Mariana D</creatorcontrib><creatorcontrib>Rios, João Pedro P</creatorcontrib><creatorcontrib>Pereira, Augusto F</creatorcontrib><creatorcontrib>Diamantino, Luciana C</creatorcontrib><creatorcontrib>Ribeiro, Antonio L</creatorcontrib><creatorcontrib>Sable, Craig A</creatorcontrib><creatorcontrib>Brant, Luisa C</creatorcontrib><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diamantino, Adriana C</au><au>Nascimento, Bruno R</au><au>Beaton, Andrea Z</au><au>Nunes, Maria Do Carmo P</au><au>Oliveira, Kaciane K</au><au>Rabelo, Lara C</au><au>Barbosa, Marcia</au><au>Reese, Alison T</au><au>Olivieri, Laura</au><au>Mata, Mariana D</au><au>Rios, João Pedro P</au><au>Pereira, Augusto F</au><au>Diamantino, Luciana C</au><au>Ribeiro, Antonio L</au><au>Sable, Craig A</au><au>Brant, Luisa C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abstract 13439: Detection of Atrial Fibrillation With a Portable Device During Cardiovascular Disease Screening in Primary Care: Data From the PROVAR + Study</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><date>2019-11-19</date><risdate>2019</risdate><volume>140</volume><issue>Suppl_1 Suppl 1</issue><spage>A13439</spage><epage>A13439</epage><pages>A13439-A13439</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>IntroductionAtrial fibrillation (AF) is the most common arrhythmia and is associated with significant morbidity. Portable devices such as MyDiagnostick® (MDS) allow for AF screening. We aimed to evaluate the sensitivity and specificity of MDS for AF diagnosis in patients in the waiting list for echocardiogram (ECHO) in primary care and to assess the prevalence of AF by this method.MethodsIn 5 days, 1,518 patients from low-income areas of Brazil underwent clinical evaluation and cardiovascular (CV) risk stratification using a study-derived score based on demographics and CV comorbidities. Patients were then screened for AF with MDS, holding the device with both hands for 1-minute. The test was considered positive when the device indicated the presence of AF. The gold-standard for AF diagnosis was the 12-lead ECG interpreted by a cardiologist. Patients with intermediate CV risk were submitted to ECHO screening with ultraportable device. Individuals with abnormalities in screening or those with high CV risk, in addition to a low-risk sample, underwent standard ECHO. Major heart disease (HD) was defined as moderate to severe valve disease, ventricular dysfunction/hypertrophy, pericardial effusion or wall-motion abnormalities.ResultsMean age was 58 ± 16 years, 66% were women. Prevalence of AF by MDS was 6.4% (N=97)higher in patients with high CV risk (12.6%), compared with moderate (6.1%) and low risk (2.2 %), p&lt;0.001. Prevalence was also higher in &gt;65-year-olds (9.3%) than in those aged 40-64 years (4.2%) and &lt;40 years (6.9%), p=0.001. Of 1,063 patients undergoing ECHO screening, 45% (N=481) had HD, whereas among 64 patients with AF in MDS undergoing ECHO, 55% had HD (p=0.12). Positive AF screening was independently associated with the presence of HD on standard ECHO (OR = 3.9, 95%CI 2.1 - 7.2, p &lt;0.001) after adjusting for sex, age and clinical variables. Compared to the ECG, the MDS had sensitivity of 97% (95%CI 86 - 100) and specificity of 69% (95%CI 61 - 76.) for AF detection.ConclusionScreening with the MDS portable device demonstrated high sensitivity for early detection of AF in primary care. Prevalence in a population referred for ECHO was high and associated with age and higher CV risk. AF at screening was independently associated with HD detected by ECHO.</abstract><pub>by the American College of Cardiology Foundation and the American Heart Association, Inc</pub><doi>10.1161/circ.140.suppl_1.13439</doi></addata></record>
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title Abstract 13439: Detection of Atrial Fibrillation With a Portable Device During Cardiovascular Disease Screening in Primary Care: Data From the PROVAR + Study
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