Abstract 13467: Ctrp9 Regulates Mitophagic Degradation Against Myocardial Ischemia/rRperfusion Injury Through Modulating Cathepsin Activity

BackgroundMitochondrial dysfunction and associated mitophagic flux disturbance contribute to myocardial ischemia/reperfusion (MI/R) injury. Cardiokine CTRP9 exerts protective effects against MI/R injury. However, it remains unclear whether and how CTRP9 regulates mitophagy.Methods and ResultsWT and...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A13467-A13467
Main Authors: Zhao, Dajun, Yi, Wei, Lau, Wayne B, Gao, Erhe, Koch, Walter J, Wang, Chunsheng, Ma, Xin L, Wang, Yajing
Format: Article
Language:English
Online Access:Get full text
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Summary:BackgroundMitochondrial dysfunction and associated mitophagic flux disturbance contribute to myocardial ischemia/reperfusion (MI/R) injury. Cardiokine CTRP9 exerts protective effects against MI/R injury. However, it remains unclear whether and how CTRP9 regulates mitophagy.Methods and ResultsWT and CTRP9 knockout (CTRP9-KO) mice were subjected to MI/R. Compared to WT, further decreased left ventricular ejection fraction (P
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.140.suppl_1.13467