Abstract 15563: Impact of Cardiovascular Events on Short and Long-Term Mortality Following Liver Transplantation

• Published in: Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A15563-A15563
• Main Authors: Sharma, Vikram, Cywinski, Jacek B, Menon, KV Narayanan, Modaresi Esfeh, Jamak E, Nair, Ravi, Parikh, Parth, Diago, Teresa, Eghtesad, Bijan, Quintini, Cristiano, Fares, Maan
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.15563

IntroductionPresent-day patients undergoing liver transplantation are older and have a higher risk of peri-operative cardiovascular events. However,data on the exact burden and impact of cardiovascular events following liver transplantation is still limitedHypothesisWe aimed to study the frequency of adverse cardiovascular events as well as their contribution to mortality in the setting of liver transplantationMethodsThis is retrospective analysis of data from a prospectively recorded database of patients who underwent liver transplantation at Cleveland Clinic between 2008- Jan 2019. In total there were 1526 patients in the final analysisResultsTotal mortality was 19.9% over a mean follow-up of 4.56 ± 3.3 years following liver transplantation. 30-day mortality was 3.3%. Median patient age was 57. Post-transplant cardiovascular complications included stroke (4.4% cases), myocardial infarction (MI) (4.5%), acute heart failure (6.9%) and arrhythmia (17.4%). Cardiovascular events associated with the highest hazard for long term mortality included acute stroke with an adjusted hazard ratio (HR) of 2.02 (Confidence Interval, CI, 1.3-3.2, p=0.002), acute MI with an adjusted HR of 1.99 (CI 1.16-3.43, p=0.012) and post-transplant acute heart failure with adjusted HR of 1.79 (CI 1.24-2.6, p=0.002). The composite of MACE (MI/Stroke/Heart failure) was noted in 13.3% patients with adjusted HR of 2.58 (CI 1.9-3.6; p